On May 23, 2019, BOC Sciences, a US-based chemical expert, announced to release lead optimization service for the science community. BOC Sciences has long been actively involved in advancing drug R&D for the wellbeing of mankind with concerted efforts from the industry. BOC Sciences has long been actively involved in advancing drug R&D for the wellbeing of mankind with concerted efforts from the industry. After this move, now scientists can have access to a wide range of medicinal chemistry and drug discovery services.
Lead optimization is one of the most important steps in drug development that follows hit identification and hit to lead and generally involves diversified operation. With lead optimization, the chemical structures of compounds or biologics can be modified to improve target’s selectivity, specificity, pharmacodynamics, pharmacokinetic and toxicological properties so as to generate the most desirable preclinical drug candidates.
“Once a molecule is identified, the next step is to check its ADMET properties. We need to figure out what characteristics the leads already have and what attributes they would also like to conclude. If the molecule has no toxicity and no mutagenicity either, it has potential for use as lead molecule. Roughly speaking, further optimization could give better quality to lead molecules, and finally develop them into drugs,” says Mr. Barron Jones, the Marketing Chief of BOC Sciences. “The most basic five attributes needed to be considered are potency, bioavailability, duration, safety, and pharmaceutical acceptability. Potency and bioavailability determine whether the compounds are able to produce a desirable pharmacological response and to pass through multiple barriers, such as the gastrointestinal tract and the liver in order to reach the target. Duration is the ability of the compound to remain in circulation (or at the target site) for sufficient time to provide a meaningful pharmacological response. Pharmaceutical acceptability implies if the drug compounds have suitable pharmaceutical properties such as adequate aqueous solubility, good chemical stability, satisfactory dissolution rate, and the like.”
Safety is also a determining factor. It is estimated that toxicity accounts for about 1/3 of the loss of candidate drugs, which is the main reason for the high cost of drug development. Most importantly, the safety issue of lead compounds cannot be fully recognized until proceeding into clinical trials.
Lead optimization conducted after lead discovery by BOC Sciences is achieved through the combination of assay development and screening, computer-aided drug design, and pharmaceutical science. With experienced experts, many problems arising from drug discovery process can also be properly resolved. For more information about BOC Sciences’ lead optimization service, please visit: https://www.solutions.bocsci.com/lead-optimization.htm.
About BOC Sciences
As a trust-worthy brand, the US-based company BOC Sciences strives to offer strategies and solutions to resolve the most pressing issues facing drug discovery and drug development. To this end, it provides comprehensive medicinal chemistry services, custom synthesis, analysis/purification, formulation services for pharmaceutical companies engaged in drug discovery and research.
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Website: https://www.solutions.bocsci.com