Amyloid light-chain (AL) amyloidosis, also known as primary amyloidosis, is the most common form of systemic amyloidosis in the US. The disease is caused when a person’s antibody-producing cells do not function properly and produce abnormal protein fibers made of components of antibodies called light chains.
The amyloid deposits in AL amyloidosis are not themselves cancerous; however, the condition may occasionally be associated with cancer called myeloma. Regardless of whether or not a patient has myeloma associated with their amyloidosis, the treatments for AL amyloidosis are similar to those for myeloma. The survival of patients with amyloidosis is quite variable, with median survival ranging from 12 months to 18 months in different series, and largely depends on the number of organs involved and the severity of their involvement.
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The AL Amyloidosis Market Research Report covers emerging drugs, current treatment practices, market share of the individual therapies, current and forecasted AL Amyloidosis market Size from 2017 to 2030 segmented by seven major markets.
The report provides a detailed current AL Amyloidosis treatment practice/algorithm, market drivers, market barriers, and unmet medical needs to curate the best of the opportunities and assess the underlying potential of the market.
AL Amyloidosis Market Key Facts
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According to a study conducted by Shimazaki et. al. (2019) titled, “Current diagnosis and treatment of AL amyloidosis in Japan: a nationwide epidemiological survey,” the incidence of AL amyloidosis, in Japan, was estimated to be 4.2/million person-years.
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As per the National organization for Rare disease information, while the incidence is thought to be equal in males and females, about 60% of patients referred to amyloid centers are male. AL amyloidosis has been reported in individuals as young as 20 years of age but is typically diagnosed at about age 50–65.
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According to the National Organization for Rare Disease, 60% of patients referred to amyloid centers are male.
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According to a study conducted by Kyle et al. (2019) titled, “Incidence of AL Amyloidosis in Olmsted County, Minnesota, 1990 through 2015,” it was observed that 35 patients were identified as having AL amyloidosis. The median age at diagnosis was 76 years (range, 38–90 years), with men accounting for 54%. The incidence rate of AL amyloidosis from 1990 to 2015 adjusted for age and sex was 1.2/100,000 person-years.
Key Benefits of AL Amyloidosis Market Report
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AL Amyloidosis market report provides an in-depth analysis of AL Amyloidosis Market Size, Share, Trend, and Epidemiology Forecast till 2030 in the seven major markets (i.e. the United States, EU5 (Germany, Italy, Spain, France, and the UK) and Japan.
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The report will help in developing business strategies by understanding the AL Amyloidosis Market Trends, recent developments, key players, and future market competition that will shape and drive the market growth in the upcoming years.
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The market report covers the AL Amyloidosis current treatment practices, emerging drugs, market share of the individual therapies in the seven major markets.
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The report provides a detailed assessment of the AL Amyloidosis market in terms of market drivers & barriers, unmet needs, market opportunities, patient population, detailed comparative analysis of pipeline products including clinical and non-clinical stage products, and other factors.
Increased awareness of this unique histology has allowed for the development of drugs that are specific and has begun to shed light on the similarities and possible unique aspects of AL Amyloidosis. These factors, along with the expected launch of emerging therapies, will boost the market in the forecast period.
The market outlook section of the report helps to build a detailed comprehension of the historic, current, and forecasted AL Amyloidosis market size and share by analyzing the impact of current therapies on the market, unmet needs, drivers, and barriers, and demand for better technology.
The report gives a thorough detail of the AL Amyloidosis market trend of each marketed drug and late-stage pipeline therapy by evaluating their impact based on the annual cost of therapy, inclusion and exclusion criteria, mechanism of action, increasing patient pool, covered patient segment, expected launch year, competition with other therapies, brand value, their impact on the market and view of the key opinion leaders.
AL Amyloidosis Epidemiology
The epidemiology section covers insights about the historical and current AL Amyloidosis patient pool and forecasted trends for every seven major countries from 2017 to 2030. It helps to recognize the causes of current and forecasted trends by exploring numerous studies and views of key opinion leaders. The epidemiology section also provides the diagnosed patient pool and their trends along with assumptions undertaken.
AL Amyloidosis Epidemiology Segmentation
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Total Incident/Prevalent Cases of AL Amyloidosis
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Gender-specific Incident/Prevalent Cases of AL Amyloidosis
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Age-specific Incident/Prevalent Cases of AL Amyloidosis
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Diagnosed and Treatable Cases of AL Amyloidosis
AL Amyloidosis Drugs Uptake and Pipeline Development Activities
The drugs uptake section focuses on the rate of uptake of the potential drugs recently launched in the AL Amyloidosis market or expected to get launched in the market during the study period. The analysis covers AL Amyloidosis market uptake by drugs; patient uptake by therapies; and sales of each drug.
Report’s Drugs Uptake section helps in understanding the drugs with the most rapid uptake, reasons behind the maximal use of new drugs and allow the comparison of the drugs on the basis of market share and size which again will be useful in investigating factors important in market uptake and in making financial and regulatory decisions.
The report also covers the AL Amyloidosis Pipeline Development Activities and provides valuable insights about different therapeutic candidates in Phase II, and Phase III stages and the key companies in the AL Amyloidosis market involved in developing targeted therapeutics. It also analyses the recent Development such as collaborations, acquisitions, and mergers, licensing patent details, and other information for AL Amyloidosis emerging therapies.
There is a strong need for regional AL Amyloidosis registration centers, which may offer consented and consistent therapy recommendations to gain more data and knowledge of this rare but threatening disease.
There is no cure for patients with AL amyloidosis, but more frequently, patients go into remission with drug therapy. It is believed that the majority of patients surviving the first 6 months can often start recovering thereafter and can typically live normal or near-normal lives for years to come.
At present some of the key companies are diligently working towards the development of therapies for AL Amyloidosis. The launch of expected emerging therapies is expected to significantly impact the amyloid light chain (“AL”) amyloidosis market during the forecast period (2020–2030).
AL Amyloidosis Companies
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Caelum Biosciences
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Spectrum Pharmaceuticals
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Millenium Pharmaceuticals
And others.
AL Amyloidosis Therapies covered in the report includes:
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CAEL-101
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Evomela/Propylene Glycol-Free Melphalan
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ixazomib in combination with cyclophosphamide and dexamethasone
And many others
Table of Content
1. Key Insights
2. Executive Summary
3. AL Amyloidosis Competitive Intelligence Analysis
4. AL Amyloidosis Market Overview at a Glance
5. AL Amyloidosis Disease Background and Overview
6. AL Amyloidosis Patient Journey
7. AL Amyloidosis Epidemiology and Patient Population
8. AL Amyloidosis Treatment Algorithm, Current Treatment, and Medical Practices
9. AL Amyloidosis Unmet Needs
10. Key Endpoints of AL Amyloidosis Treatment
11. AL Amyloidosis Marketed Products
12. AL Amyloidosis Emerging Therapies
13. AL Amyloidosis Seven Major Market Analysis
14. Attribute Analysis
15. AL Amyloidosis Market Outlook (7 major markets)
16. AL Amyloidosis Access and Reimbursement Overview
17. KOL Views on the AL Amyloidosis Market.
18. AL Amyloidosis Market Drivers
19. AL Amyloidosis Market Barriers
20. Appendix
21. DelveInsight Capabilities
22. Disclaimer
*The table of contents is not exhaustive; the final content may vary.
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