Intrahepatic Cholangiocarcinoma (ICCA), a primary malignant neoplasm of the liver secondary to hepatocellular carcinoma, arises from the intrahepatic biliary epithelium (lining epithelia and peribiliary glands) and shows a variable cholangiocytic differentiation. The malignant tumor may arise from any portion of the bile duct epithelium, i.e., anywhere from the terminal ductules (canals of Hering) to the ampulla of Vater, as well as at the peribiliary glands (intramural and extramural).
DelveInsight’s ‘ Intrahepatic Cholangiocarcinoma Market Insights, Epidemiology, and Market Forecast 2030 ‘ report deliver an in-depth understanding of the ICCA, historical and forecasted epidemiology as well as the ICCA market trends in the United States, EU5 (Germany, France, Italy, Spain, and the United Kingdom) and Japan.
Some facts of Intrahepatic Cholangiocarcinoma Market Report:
- In 2017, a total of 10,177 patients were affected with ICCA in the 7MM.
- The United States contributes the largest share with 3,639 incident cases in 2017, acquiring about 35.76% of the totals 7MM share. On the other hand, EU5 and Japan will account for 37.40% and 26.84% population share, respectively, by 2017.
- The Intrahepatic Cholangiocarcinoma market size in the 7MM was USD 99.78 million in 2017.
- Among the 7MM, the United States accounts for the highest market size of ICCA in comparison with EU5 and Japan.
- ICCA is slightly common in males as compared to females.
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Intrahepatic Cholangiocarcinoma Companies involved:
- Incyte Corporation
- Roche
- Delcath Systems
- Basilea Pharmaceutica
- Agios Pharmaceuticals
- Bayer
- Loxo Oncology/Bayer
- QED Therapeutics
- Janssen Pharmaceutical
- Taiho Oncology
- RedHill Biopharma
- GlaxoSmithKline
- Merck/GlaxoSmithKline
- Eisai
- Taiho Pharmaceutical/Servier
- Bayer
- Sorrento Therapeutics/Yuhan Corporation
- Hutchison Medipharma
- Jiangsu HengRui Medicine
- AstraZeneca
- Eli Lilly
- Servier Laboratories
- Genoscience Pharma
- Forma Therapeutics
- Array BioPharma
- And Many Others
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Intrahepatic Cholangiocarcinoma Market Outlook
Intrahepatic cholangiocarcinoma (ICCA) is the type of CCA that forms in the bile ducts inside the liver. The commonly available modalities for the treatment of ICCA include surgery and radiation therapies for curative intent and systemic therapies, including chemotherapy and chemoradiotherapy, for the surgery of ineligible patients.
Surgical resection is the mainstay for the treatment of ICCA. The main goal of the surgery is the hepatic resection with negative margins. Since this type of cancer occurs in the bile ducts inside the liver, surgery may include removing the section or wedge of the liver, and its extent depends on tumor size and location.
Locoregional therapies such as RFA, TACE, DEB-TACE or TACE drug-eluting microspheres, and TARE with yttrium-90 microspheres have shown to be effective in a retrospective analysis of patients with ICCA. Besides these, radiation therapy is also a locoregional treatment option for unresectable ICCA. Fewer patients with ICCA are also given ablation. Although all guidelines recommend radiofrequency ablation (RFA) as a standard treatment for patients with small, early-stage HCC not suitable for surgical therapies, in some cases, patients with ICCA are also treated with RFA.
Intrahepatic Cholangiocarcinoma Therapies:
- Pemazyre (Pemigatinib)
- Rozlytrek (Entrectinib)
- Melphalan/HDS
- Derazantinib
- Ivosidenib
- Regorafenib
- Larotrectinib
- Infigratinib
- Balversa (Erdafitinib)
- Futibatinib (TAS-120)
- Opaganib (ABC294640; Yeliva)
- Niraparib (Zejula)
- Bintrafusp alfa (GSK4045154; M7824)
- E7090
- Lonsurf (Trifluridine and Tipiracil Hydrochloride/TAS-102)
- Copanlisib (BAY 80-6946)
- STI-3031 (IMC-001)
- HMPL-453
- Famitinib
- Durvalumab
- Abemaciclib
- Nal-IRI with 5-fluorouracil and/or Leucovorin
- GNS561
- Olutasidenib (FT-2102)
- Gemcitabine, Cisplatin, and MEK162
- And Many Others
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Table of contents:
- Key Insight
- Executive Summary of Intrahepatic Cholangiocarcinoma (ICCA)
- Intrahepatic Cholangiocarcinoma (ICCA) Market Overview at a Glance
- Disease Background and Overview: Intrahepatic Cholangiocarcinoma (ICCA)
- Case Reports
- Intrahepatic Cholangiocarcinoma (ICCA) Epidemiology and Patient Population
- United States Epidemiology
- EU5 Epidemiology
- Japan Epidemiology
- Current Intrahepatic Cholangiocarcinoma (ICCA) Treatment and Medical Practices
- Unmet needs
- Intrahepatic Cholangiocarcinoma (ICCA) Marketed Drugs
- Intrahepatic Cholangiocarcinoma (ICCA) Emerging Drugs
- Intrahepatic Cholangiocarcinoma (ICCA) 7MM Market Analysis
- United States
- EU-5 countries: Market Outlook
- Japan Market Outlook
- Intrahepatic Cholangiocarcinoma (ICCA) Market Drivers
- Intrahepatic Cholangiocarcinoma (ICCA) Market Barriers
- SWOT Analysis
- Reimbursement and market access
- Appendix
- DelveInsight Capabilities
- Disclaimer
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