DelveInsight’s, “Metastatic Castration-Resistant Prostate Cancer Pipeline Insight 2023,” report provides comprehensive insights about 75+ companies and 75+ pipeline drugs in Metastatic Castration-Resistant Prostate Cancer pipeline landscape. It covers the pipeline drug profiles, including clinical and nonclinical stage products. It also covers the therapeutics assessment by product type, stage, route of administration, and molecule type. It further highlights the inactive pipeline products in this space.
For Metastatic Castration Resistant Prostate Cancer Emerging drugs, the Metastatic Castration Resistant Prostate Cancer pipeline analysis report provides a 360° view of the therapeutics landscape by development point, product type, route of administration, molecule type, and MOA. The Metastatic Castration Resistant Prostate Cancer pipeline research covers business opportunities, challenges, future partnerships, strong competitors, and growth strategies.
In the Metastatic Castration Resistant Prostate Cancer Pipeline Report, a detailed description of the drug is given which includes the mechanism of action of the drug, Metastatic Castration Resistant Prostate Cancer clinical trials studies, Metastatic Castration Resistant Prostate Cancer NDA approvals (if any), and product development activities comprising the technology, Metastatic Castration Resistant Prostate Cancer collaborations, licensing, mergers and acquisition, funding, designations, and other product-related details.
Key takeaways from the Metastatic Castration Resistant Prostate Cancer Pipeline Report
- DelveInsight’s Metastatic Castration-Resistant Prostate Pipeline Report depicts a robust space with 75+ active players working to develop 75+ pipeline therapies for metastatic castration-resistant prostate cancer treatment.
- The leading Metastatic Castration-Resistant Prostate Companies are working in the market include AstraZeneca, Hinova pharmaceuticals, POINT Biopharma, Exelixis, Tavanta Therapeutics, Pfizer, Zenith Epigenetics, Surface Oncology, Opna-IO LLC, Taiho oncology, Arvinas, Forma therapeutics, ESSA Pharma, Oncternal, Janux Therapeutics, Blue Earth Therapeutics, Arcus Biosciences, Fortis therapeutics, Amgen, Regeneron Pharmaceuticals, Veru Inc, Constellation Pharmaceuticals, Noxopharm Limited, Immunic AG, Accutar Biotechnology Inc, Hinova pharmaceuticals, Novartis, Nuvation Bio, Bayer, Cardiff Oncology, Astellas Pharma, Hoffman-La-Roche, Modra Pharmaceuticals, Bristol Myers Squibb, Bellicum Pharmaceuticals and others are developing novel drug candidates to improve the metastatic castration-resistant prostate cancer treatment landscape.
- Promising Metastatic Castration-Resistant Prostate Pipeline Therapies includes Capivasertib, TAVT-45, HC-1119, PNT2002, Cabozantinib, TAVT-45, ZEN-3694, SRF 617, PLX2853, REGN5678, VERU-100, CPI-1205, NOX66, IMU-935, AC176, HP518, NZV930, NIR178, NUV 422, XL092, VERU-111, BAY2315497, Onvansertib, Enfortumab vedotin, Talazoparib, and others.
- The Metastatic Castration-Resistant Prostate Companies and academics are working to assess challenges and seek opportunities that could influence R&D Metastatic Castration Resistant Prostate cancer. The Metastatic Castration-Resistant Prostate pipeline therapies under development are focused on novel approaches to treat/improve Metastatic Castration Resistant Prostate cancer.
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Metastatic Castration Resistant Prostate Cancer Overview
Prostate cancer (PCa) is one of the most prevalent malignancies in the world and the third most common cause of male cancer-related death in the United States of America (USA). The majority of men with newly diagnosed PCa present with localized disease and undergo radical prostatectomy and/or radiological therapy, followed by androgen deprivation therapy (ADT). Depending on the grade of the cancer, a variable percentage of these patients experience progression to castration-resistant prostate cancer (CRPC) within 10 years.
Recent Developmental Activities in the Metastatic Castration-Resistant Prostate Cancer Treatment Landscape
- In January 2022, Hinova Pharmaceuticals announced that the first patient with metastatic castration-resistant prostate cancer (mCRPC) had been successfully dosed in Phase I clinical trial of HP518, a highly selective and orally bioavailable chimeric degrader targeting androgen receptor (AR). The ongoing open-label Phase I study in Australia will evaluate the safety, pharmacokinetics, and anti-tumor activity of HP518 in patients with mCRPC.
- In December 2021, Accutar Biotechnology announced the FDA clearance of the IND application for Phase I Trial of AC0176 in prostate cancer. Accutar expects to begin enrollment in Phase 1 clinical trial for AC0176 in the first quarter of 2022.
- In April 2022, Janssen announced the submission of a Marketing Authorisation Application (MAA) to the European Medicines Agency (EMA) seeking approval of niraparib in combination with abiraterone acetate, in the form of a dual-action tablet plus prednisone, based on the results of the Phase III MAGNITUDE study for the treatment of patients with prostate cancer who have progressed to metastatic castration-resistant prostate cancer (mCRPC) and are positive for homologous recombination repair (HRR) gene alterations. In April 2016, Janssen Biotech, Inc. entered a worldwide (except Japan) collaboration and license agreement with TESARO, Inc. (acquired by GSK in 2018), for exclusive rights to niraparib in prostate cancer.
- In May 2022, Janux Therapeutics announced that the US Food and Drug Administration (FDA) cleared the Company’s investigational new drug (IND) application for its lead product candidate, JANX007, a PSMA-TRACTr in development for the treatment of metastatic castration-resistant prostate cancer (mCRPC). JANX007 is the Company’s lead novel T cell engager (TCE) therapeutic from its TRACTr platform. Janux plans to initiate a Phase I clinical trial for JANX007 in the second half of 2022.
- In June 2022, Blue Earth Therapeutics announced results from a series of preclinical analyses designed to evaluate the biodistribution and potential therapeutic efficacy of 177Lu-rhPSMA-10.1 and 177Lu-PSMA-I&T in the treatment of prostate cancer preclinical models. In April 2022, the FDA cleared an investigational new drug application for 177Lu-rhPSMA-10.1 as a potential therapeutic option for patients with metastatic castration-resistant prostate cancer (mCRPC).
- Oncternal is supporting an investigator-sponsored study being conducted at the UC San Diego School of Medicine, a Phase Ib clinical trial of zilovertamab in combination with docetaxel for patients with metastatic castration-resistant prostate cancer (mCRPC). In addition, it is also developing ONCT-534, a dual-action androgen receptor inhibitor (DAARI), that is in preclinical development as a potential treatment for castration-resistant prostate cancers, including those with clinically important resistance to approved androgen receptor inhibitors.
- In June 2022, ESSA Pharma Inc. presented clinical results from the Phase Ia dose-escalation study of EPI-7386, ESSA’s first-in-class N-terminal domain androgen receptor inhibitor, as a monotherapy for the treatment of patients with metastatic castration-resistant prostate cancer resistant to current standard-of-care therapies. The initial data from 36 patients demonstrated that EPI-7386 was well-tolerated, exhibited a favorable pharmacokinetic profile, and demonstrated initial anti-tumor activity in a heavily pretreated group of patients. ESSA expects to initiate the Phase Ib expansion study in Q3 2022.
- In May 2022, Arcus Biosciences reported that data analysis from the randomized cohort of ARC-6 evaluating etrumadenant plus zimberelimab and docetaxel versus docetaxel in second-line metastatic castrate-resistant prostate cancer (CRPC) is anticipated in the second half of 2022 with a presentation of results expected in 2023.
- In February 2022, Arvinas reported that the novel androgen receptor (AR) PROTAC degrader, bavdegalutamide (ARV-110), was found to be clinically active and tolerable with manageable adverse effects (AEs) in Phase I/II clinical trial in patients with metastatic castration-resistant prostate cancer (mCRPC) following 1 to 2 prior novel hormonal drugs.
- In March 2022, Forma therapeutics reported positive results from Phase I clinical trial evaluating FT-7051. It was well tolerated with signs of clinical activity and continues to enroll men with metastatic castration-resistant prostate cancer (mCRPC). The first evaluable patient completing 12 weeks of treatment demonstrated a >80% decline in prostate-specific antigen (PSA80) from baseline at 16 weeks with stable disease. As of May 2022, 25 patients were enrolled in the Phase I dose-escalation trial, assessing the predicted efficacious exposure range supported by target engagement. Future trial enrollment to include less heavily pre-treated patients and alternative dosing schedules to address adverse events, with updated results expected in the first half of 2023.
For further information, refer to the detailed Metastatic Castration Resistant Prostate Cancer Drugs Launch, Metastatic Castration Resistant Prostate Cancer Developmental Activities, and Metastatic Castration Resistant Prostate Cancer News, click here for Metastatic Castration Resistant Prostate Cancer Ongoing Clinical Trial Analysis
Metastatic Castration Resistant Prostate cancer Emerging Drugs
- SRF617: Surface Oncology
SRF617 is a fully human antibody designed to inhibit the enzymatic activity of CD39 in the tumor microenvironment, allowing for a dual mechanism of action to promote anti-tumor immunity via reduction of immunosuppressive adenosine in addition to increasing levels of immunostimulatory ATP. SRF617 has been granted Orphan Drug designation for the treatment of advanced pancreatic cancer by the FDA.
- Rucaparib: Clovis Oncology
Rucaparib is an oral, small molecule inhibitor of PARP1, PARP2 and PARP3 being developed in multiple tumor types, including ovarian and metastatic castration-resistant prostate cancers, as monotherapy, and in combination with other anti-cancer agents. Exploratory studies in other tumor types are also underway.
- HP518: Hinova Pharmaceuticals
HP518, a highly selective and orally bioavailable chimeric degrader targeting androgen receptor (AR) with the potential to overcome the drug resistance of prostate cancer due to some specific AR mutations. In discovery and preclinical studies, HP518 showed high degradation activity against wild type AR and some specific AR mutants that are resistant to enzalutamide, and excellent antitumor activity in xenograft mouse models. HP518 is highly selective for AR.
Metastatic Castration Resistant Prostate Cancer Therapeutic Assessment
There are approx. 75+ key companies which are developing the therapies Metastatic Castration Resistant Prostate cancer. The companies which have their Metastatic Castration Resistant Prostate cancer drug candidates in the most advanced stage, i.e phase III include Clovis Oncology.
Find out more about the Metastatic Castration Resistant Prostate Cancer Pipeline Segmentation, Therapeutics Assessment, and Metastatic Castration Resistant Prostate Cancer Emerging Drugs @ Metastatic Castration Resistant Prostate Cancer Treatment Landscape
Scope of the Metastatic Castration-Resistant Prostate Cancer Pipeline Report
- Coverage- Global
- Metastatic Castration-Resistant Prostate Cancer Companies- AstraZeneca, Hinova pharmaceuticals, POINT Biopharma, Exelixis, Tavanta Therapeutics, Pfizer, Zenith Epigenetics, Surface Oncology, Opna-IO LLC, Taiho oncology, Arvinas, Forma therapeutics, ESSA Pharma, Oncternal, Janux Therapeutics, Blue Earth Therapeutics, Arcus Biosciences, Fortis therapeutics, Amgen, Regeneron Pharmaceuticals, Veru Inc, Constellation Pharmaceuticals, Noxopharm Limited, Immunic AG, Accutar Biotechnology Inc, Hinova pharmaceuticals, Novartis, Nuvation Bio, Bayer, Cardiff Oncology, Astellas Pharma, Hoffman-La-Roche, Modra Pharmaceuticals, Bristol Myers Squibb, Bellicum Pharmaceuticalsand others.
- Metastatic Castration-Resistant Prostate Cancer Pipeline Therapies- Disitamab Vedotin, EndoTAG®-1 (SB05), Stenoparib (2X-121), U3-1402, KN026, trastuzumab duocarmazine, HS-10342, MRG002, ARX788, DHP107, PMD-026, PVX-410, HX008, Tenalisib, MEN1611, SM-88, HMPL-013, ODM-209, HC-5404-FU, RP12146, PU-H71, NOV120101, SC10914, Eftilagimod Alpha, ARV-471, E7090, DZD1516, G1T38, Sitravatinib, TQ-B211, B003, PF-06873600, OTS167PO, AND019, DAN-222, Enobosarm, Futibatinib, LY3484356, Lasofoxifene, MCLA-128, huMNC2-CAR44 CAR T cells, REM-001, GNC-035, RGT-419B, Hemay022, SCR-6852, and others.
- Metastatic Castration-Resistant Prostate Cancer Segmentation- Product Type, Molecule Type, Mechanism of Action, Route of Administration
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Table of Content
- Introduction
- Executive Summary
- Metastatic Castration Resistant Prostate cancer: Overview
- Pipeline Therapeutics
- Therapeutic Assessment
- Metastatic Castration Resistant Prostate cancer– DelveInsight’s Analytical Perspective
- Late Stage Products (Phase III)
- Rucaparib: Clovis Oncology
- Drug profiles in the detailed report…..
- Mid Stage Products (Phase II)
- Surface Oncology: SRF 617
- Drug profiles in the detailed report…..
- Early Stage Products (Phase I/II)
- REGN 4336: Regeneron Pharamceuticals
- Drug profiles in the detailed report…..
- Early Stage Products (Phase I)
- HP 518: Hinova Pharmaceuticals
- Drug profiles in the detailed report…..
- Inactive Products
- Metastatic Castration Resistant Prostate cancer Key Companies
- Metastatic Castration Resistant Prostate cancer Key Products
- Metastatic Castration Resistant Prostate cancer- Unmet Needs
- Metastatic Castration Resistant Prostate cancer- Market Drivers and Barriers
- Metastatic Castration Resistant Prostate cancer- Future Perspectives and Conclusion
- Metastatic Castration Resistant Prostate cancer Analyst Views
- Metastatic Castration Resistant Prostate cancer Key Companies
- Appendix
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