DelveInsight’s, “Extensive Stage Small Cell Lung Cancer Pipeline Insight 2023,” report provides comprehensive insights about 40+ companies and 40+ pipeline drugs in the Extensive Stage Small Cell Lung Cancer (ESCLC) pipeline landscape. It covers the Extensive Stage Small Cell Lung Cancer pipeline drug profiles, including Extensive Stage Small Cell Lung Cancer clinical trials and nonclinical stage products. It also covers the Extensive Stage Small Cell Lung Cancer pipeline therapeutics assessment by product type, stage, route of administration, and molecule type. It further highlights the inactive pipeline products in this space.
For Extensive-Stage Small Cell Lung Cancer Emerging drugs, the Extensive-Stage Small Cell Lung Cancer pipeline analysis report provides a 360° view of the therapeutics landscape by development point, product type, route of administration, molecule type, and MOA. The Extensive-Stage Small Cell Lung Cancer pipeline research covers business opportunities, challenges, future partnerships, strong competitors, and growth strategies.
In the Extensive-Stage Small Cell Lung Cancer Pipeline Report, a detailed description of the drug is given which includes the mechanism of action of the drug, Extensive-Stage Small Cell Lung Cancer clinical trials studies, Extensive-Stage Small Cell Lung Cancer NDA approvals (if any), and product development activities comprising the technology, Extensive-Stage Small Cell Lung Cancer collaborations, licensing, mergers and acquisition, funding, designations, and other product-related details.
Key takeaways from the Extensive-Stage Small Cell Lung Cancer Pipeline Report
- DelveInsight’s Extensive-Stage Small Cell Lung Cancer pipeline report depicts a robust space with 40+ active players working to develop 40+ pipeline therapies for Extensive-Stage Small Cell Lung Cancer treatment.
- The leading Extensive-Stage Small Cell Lung Cancer Companies includes Eli Lilly and Company, Genentech, Bristol-Myers Squibb, Henlix Biotech, CSPC ZhongQi Pharmaceutical Technology Co., Ltd., BioNTech SE, Xencor, Inc., Haihe Biopharma Co., Ltd., Taizhou HoudeAoke Biomedical Co., Ltd., Celgene, MedImmune, Xcovery Holding Company, LLC, Lee’s Pharmaceutical Limited, Merck & Co, Astex Pharmaceuticals, and others.
- Promising Extensive-Stage Small Cell Lung Cancer Pipeline Therapies includes Trilaciclib, Obatoclax, Carboplatin/etoposide, QL1706, Carboplatin, HLX10, SHR-1316, Atezolizumab, Vorolanib, XmAb18087 ± Pembrolizumab, XmAb18087, and others.
- The Extensive-Stage Small Cell Lung Cancer companies and academics are working to assess challenges and seek opportunities that could influence Extensive-Stage Small Cell Lung Cancer R&D. The Extensive-Stage Small Cell Lung Cancer pipeline therapies under development are focused on novel approaches to treat/improve Extensive-Stage Small Cell Lung Cancer.
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Extensive-Stage Small Cell Lung Cancer Overview
Extensive Stage Small Cell Lung Cancer (ESCLC) is in the stage where it has spread to other parts of the body, such as the other lung or the brain. Without treatment, the average life expectancy for a person with an extensive-stage small cell lung cancer diagnosis is two to four months. The liver, adrenal glands, and bone are also common sites of metastasis.
Recent Developmental Activities in the Extensive-Stage Small Cell Lung Cancer Treatment Landscape
- In April 2022, Shanghai Henlius Biotech, announced that the New Drug Application of HANSIZHUANG (serplulimab), a novel anti-PD-1 monoclonal antibody (mAb) independently developed by the company, in combination with chemotherapy for the first-line treatment of Extensive-stage Small Cell Lung cancer (ES-SCLC) has been accepted by the National Medical Products Administration (NMPA). Henlius has also planned to file MAA in the EU in 2022. In April 2022, FDA has granted Orphan-Drug Designation for HANSIZHUANG for the treatment of SCLC, benefiting the continuous development of HANSIZHUANG.
- In March 2022, Akesobio entered into a collaboration agreement with Shenzhen Chipscreen Biosciences to conduct a Phase Ib/II clinical study of combination therapy of Cadonilimab (PD-1/CTLA-4 bispecific antibody, AK104) and Chiauranib (a highly selective Aurora B/VEGFR/PDGFR /c-Kit/CSF1R inhibitor) in patients with ES-SCLC which progressed on combination therapy of platinum-based chemotherapy and PD-(L) 1 inhibitor as first-line treatment.
- In October 2021, Jiangsu Hengrui Pharmaceuticals reported positive data of a Phase III study, demonstrating that the investigational anti-PD-L1 mAb adebrelimab (SHR-1316) in combination with etoposide and carboplatin (EC) compared with placebo in combination with EC met the primary endpoint of overall survival (OS) as first-line treatment for extensive-stage small cell lung cancer. Hengrui has submitted a pre-New Drug Application meeting request to China National Medical Products Administration based on the positive data.
- BioNTech is evaluating BNT411 as a monotherapy in patients with solid tumors and in combination with atezolizumab, carboplatin and etoposide in patients with chemotherapy-naïve extensive-stage small cell lung cancer. In July 2021, BNT411 demonstrated an acceptable safety profile at all doses tested as a monotherapy and in combination with atezolizumab, carboplatin and etoposide.
- In March 2021, China’s National Medical Products Administration cleared Lee’s Pharm to conduct a Phase III, multicenter, randomized, double blinded, parallel-group clinical trial of Socazolimab (anti-PD-L1 monoclonal antibody, formerly known as ZKAB001) combined with chemotherapy in the first-line treatment of extensive-stage small-cell lung cancer.
For further information, refer to the detailed Extensive-Stage Small Cell Lung Cancer Drugs Launch, Extensive-Stage Small Cell Lung Cancer Developmental Activities, and Extensive-Stage Small Cell Lung Cancer News, click here for Extensive-Stage Small Cell Lung Cancer Ongoing Clinical Trial Analysis
Extensive Stage Small Cell Lung Cancer Emerging Drugs Analysis
- LY 2510924: Eli Lilly and Company
LY-2510924 is an inhibitor of CXC chemokine receptor 4 (CXCR4), with potential antineoplastic activity. Upon subcutaneous administration, CXCR4 inhibitor LY-2510924 binds to the chemokine receptor CXCR4, thereby preventing CXCR4 binding to its ligand, stromal derived factor-1 (SDF-1), and subsequent receptor activation.
- Tiragolumab: Genentech
Tiragolumab is a monoclonal antibody designed to bind with TIGIT, a protein receptor on immune cells. Tiragolumab works as an immune amplifier, by potentially enhancing the body’s immune response. By binding to TIGIT, tiragolumab blocks its interaction with a protein called poliovirus receptor (PVR, or CD155) that can suppress the body’s immune response. Blockade of TIGIT and PD-L1 may synergistically enable the re-activation of T cells and enhance NK cell anti-tumor activity. It is in phase 3 stage of development for the treatment of Extensive-Stage Small Cell Lung Cancer.
Extensive-Stage Small Cell Lung Cancer Pipeline Therapeutics Assessment
There are approx. 40+ key companies which are developing the therapies for Extensive Stage Small Cell Lung Cancer (ESCLC). The companies which have their Extensive Stage Small Cell Lung Cancer (ESCLC) drug candidates in the most advanced stage, i.e. phase III include, Genentech.
Find out more about the Extensive-Stage Small Cell Lung Cancer Pipeline Segmentation, Therapeutics Assessment, and Extensive-Stage Small Cell Lung Cancer Emerging Drugs @ Extensive-Stage Small Cell Lung Cancer Treatment Landscape
Scope of the Extensive-Stage Small Cell Lung Cancer Pipeline Report
- Coverage- Global
- Extensive-Stage Small Cell Lung CancerCompanies- Eli Lilly and Company, Genentech, Bristol-Myers Squibb, Henlix Biotech, CSPC ZhongQi Pharmaceutical Technology Co., Ltd., BioNTech SE, Xencor, Inc., Haihe Biopharma Co., Ltd., Taizhou HoudeAoke Biomedical Co., Ltd., Celgene, MedImmune, Xcovery Holding Company, LLC, Lee’s Pharmaceutical Limited, Merck & Co, Astex Pharmaceuticals, and others.
- Extensive-Stage Small Cell Lung Cancer Pipeline Therapies- Trilaciclib, Obatoclax, Carboplatin/etoposide, QL1706, Carboplatin, HLX10, SHR-1316, Atezolizumab, Vorolanib, XmAb18087 ± Pembrolizumab, XmAb18087, and others.
- Extensive-Stage Small Cell Lung Cancer Pipeline Segmentation: Product Type, Molecule Type, Route of Administration, Mechanism of Action
Dive deep into rich insights for drugs for Extensive-Stage Small Cell Lung Cancer Pipeline Companies and Therapies, click here @ Extensive-Stage Small Cell Lung Cancer Unmet Needs and Analyst Views
Table of Content
- Introduction
- Executive Summary
- Extensive Stage Small Cell Lung Cancer (ESCLC): Overview
- Pipeline Therapeutics
- Therapeutic Assessment
- Late Stage Products (Phase III)
- Tiragolumab: Genentech
- Drug profiles in the detailed report…..
- Mid Stage Products (Phase II)
- LY 2510924: Eli Lilly and Company
- Drug profiles in the detailed report…..
- Early Stage Products (Phase I)
- SYHA 1807: CSPC ZhongQi Pharmaceutical Technology
- Drug profiles in the detailed report…..
- Inactive Products
- Extensive Stage Small Cell Lung Cancer (ESCLC) Key Companies
- Extensive Stage Small Cell Lung Cancer (ESCLC) Key Products
- Extensive Stage Small Cell Lung Cancer (ESCLC)- Unmet Needs
- Extensive Stage Small Cell Lung Cancer (ESCLC)- Market Drivers and Barriers
- Extensive Stage Small Cell Lung Cancer (ESCLC)- Future Perspectives and Conclusion
- Extensive Stage Small Cell Lung Cancer (ESCLC) Analyst Views
- Extensive Stage Small Cell Lung Cancer (ESCLC) Key Companies
- Appendix
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