The Epilepsy Pipeline report embraces in-depth commercial and clinical assessment of the pipeline products from the pre-clinical developmental phase to the marketed phase. The report also covers a detailed description of the drug, including the mechanism of action of the drug, clinical studies, NDA approvals (if any), and product development activities comprising the technology, collaborations, mergers acquisition, funding, designations, and other product-related details.

“Epilepsy Pipeline Insight, 2023“ report by DelveInsight outlines comprehensive insights into the present clinical development scenario and growth prospects across the Epilepsy Market.

Some of the key takeaways from the Epilepsy Pipeline Report:

• Companies across the globe are diligently working toward developing novel Epilepsy treatment therapies with a considerable amount of success over the years. 
• Epilepsy companies working in the treatment market are Elium Therapeutics, CombiGene, Ovid Therapeutics, Otsuka Pharmaceutical Co.,Ltd., SK Biopharmaceutical, Receptor Life Sciences, Cerebral Therapeutics, Equilibre Biopharmaceutical, Cerevel Therapeutics, Engrail Therapeutics, Amzell, Xenon Pharmaceuticals Inc., Engage Therapeutics, Takeda Pharmaceuticals, GW Pharmaceuticals, Equilibre Biopharmaceuticals, Avicanna, and others, are developing therapies for the Epilepsy treatment 

• Emerging Epilepsy therapies in the different phases of clinical trials are- Kv7 Program, CG 01, OV329, OPC-214870, SKL24741, RLS103, CT-010, EQU 001, Darigabat, ENX-101, AMZ002, XEN496, Alprazolam inhalation, XEN1101, TAK-935, Cannabidivarin, EQU-001, AVCN-319302, and others are expected to have a significant impact on the Epilepsy market in the coming years.   
• In January 2023, In order to assess the efficacy and safety of AMZ002 in the treatment of infantile spasms, a rare form of epilepsy, Amzell started a randomised, open-label superiority study. The primary goal of this study is to compare AMZ002 and Vigabatrin for treating infantile spasms (IS) in participants who have just received a diagnosis.
• In March 2023, IAMA Therapeutics, a preclinical-stage pharmaceutical company focused on the discovery, development, and commercialization of novel medicines to make a difference in the lives of individuals suffering from brain disorders, announced that preclinical data supporting its IAMA-6 program in focal refractory epilepsy will be presented at the 75th American Academy of Neurology (AAN) Annual Meeting, taking place on April 22-27 in Boston, Massachusetts.
• In February 2023, The Phase 2 clinical study of ADX71149 (JNJ-40411813) for the treatment of epilepsy was completed, according to an announcement from Addex Therapeutics. Metabotropic glutamate type 2 (mGlu2) receptor-positive allosteric modulator (PAM) ADX71149 is selective. The experiment is being run by Janssen Pharmaceuticals, Inc., a subsidiary of Johnson & Johnson’s Janssen Pharmaceutical Companies.
• In January 2023, EQU-001, a novel anti-inflammatory anti-seizure drug, is administered as once-daily oral adjunctive therapy for focal seizures in adults with epilepsy. Equilibre Biopharmaceuticals Corp. reported positive topline results from the Phase 2 clinical trial evaluating the clinical safety, tolerability, and preliminary efficacy of EQU-001. The EQU-001 study’s findings are positive since they show outstanding tolerability and encouraging efficacy for adult patients with focal epilepsy, particularly for those who have seizures that are challenging to manage.
• In January 2023, In order to make epilepsy studies easier for patients and research sites to participate in while providing reliable outcome assessment data to support trial endpoints, Signant Health devised a revolutionary electronic diary (eDiary) data gathering method. The new patient-reported outcome measure, which was created in partnership with The Epilepsy Study Consortium (TESC), provides clinical research sponsors and organisations with a standardised method for gathering high-quality data on common seizure data items.
• In June 2022, Preclinical research from CODA Biotherapeutics, Inc.’s focal epilepsy programme showed that using the company’s lead-engineered receptor and small molecule activator medication considerably decreased the frequency of focal seizures in vivo. The pharmacokinetics of the activator medication in mice models were shown to be consistent with the quick reduction in seizures, according to the results. Data also showed a strong correlation between a decrease in seizure frequency and the expression of CODA’s lead receptor.
• In September 2022, In order to investigate the effectiveness of Avicanna’s proprietary formulations in pre-clinical models for epilepsy, Avicanna Inc. is happy to announce that it has expanded its research collaboration in the field of epilepsy with a new collaboration with the University of Toronto and Dr. Mac Burnham’s research team. The efficacy of Avicanna’s medication candidates, including AVCN319302, in animal models for epilepsy will be investigated by the research cooperation headed by Dr. Mac Burnham’s team.
• In March 2021, In order to evaluate the efficacy, safety, and tolerability of XEN496 administered as an adjunctive treatment in about 40 paediatric patients with KCNQ2-DEE aged one month to less than six years, Xenon Pharmaceuticals began a randomised, double-blind, placebo-controlled, parallel-group, multicenter clinical trial.

Epilepsy Overview

A chronic neurological condition called epilepsy is characterised by frequent, recurrent convulsions that cause strange behaviour. Due to the various seizure forms, underlying conditions, and varying degrees of severity, it may qualify as a spectrum disorder. In epilepsy, abnormal or excessive electrical discharges from brain cells cause the brain’s function to be interrupted.

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Emerging Epilepsy Drugs Under Different Phases of Clinical Development Include:

• Kv7 Program: Elium Therapeutics
• CG 01: CombiGene
• OV329: Ovid Therapeutics
• OPC-214870: Otsuka Pharmaceutical Co.,Ltd.
• SKL24741: SK Biopharmaceutical
• RLS103: Receptor Life Sciences
• CT-010: Cerebral Therapeutics
• EQU 001: Equilibre Biopharmaceutical
• Darigabat: Cerevel Therapeutics
• ENX-101: Engrail Therapeutics
• AMZ002: Amzell
• XEN496: Xenon Pharmaceuticals Inc.
• Alprazolam inhalation: Engage Therapeutics
• XEN1101: Xenon Pharmaceuticals
• TAK-935: Takeda Pharmaceuticals
• Cannabidivarin: GW Pharmaceuticals
• EQU-001: Equilibre Biopharmaceuticals
• AVCN-319302: Avicanna

Epilepsy Route of Administration

Epilepsy pipeline report provides the therapeutic assessment of the pipeline drugs by the Route of Administration. Products have been categorized under various ROAs, such as 

• Oral
• Intravenous
• Subcutaneous
• Parenteral
• Topical

Epilepsy Molecule Type

Epilepsy Products have been categorized under various Molecule types, such as

• Recombinant fusion proteins
• Small molecule
• Monoclonal antibody
• Peptide
• Polymer
• Gene therapy 

Epilepsy Pipeline Therapeutics Assessment

• Epilepsy Assessment by Product Type
• Epilepsy By Stage and Product Type
• Epilepsy Assessment by Route of Administration
• Epilepsy By Stage and Route of Administration
• Epilepsy Assessment by Molecule Type
• Epilepsy by Stage and Molecule Type

DelveInsight’s Epilepsy Report covers around 95+ products under different phases of clinical development like

• Late-stage products (Phase III)
• Mid-stage products (Phase II)
• Early-stage product (Phase I)
• Pre-clinical and Discovery stage candidates
• Discontinued & Inactive candidates
• Route of Administration

Further Epilepsy product details are provided in the report. Download the Epilepsy pipeline report to learn more about the emerging Epilepsy therapies

Some of the key companies in the Epilepsy Therapeutics Market include:

Key companies developing therapies for Epilepsy are – Alexza Pharmaceuticals, Xenon Pharmaceuticals, GW Pharmaceuticals, Equilibre Biopharmaceuticals, Takeda Pharmaceuticals, Abide therapeutics, Otsuka pharmaceutical, H. Lundbeck A/S, Spark Therapeutics,  Equilibre Biopharmaceuticals,  ES Therapeutics, Supernus Pharmaceuticals, Inc., MGC Pharmaceuticals, Engrail Therapeutics INC, SK biopharmaceuticals, Longboard Pharmaceuticals, Janssen Research & Development, LLC, Equilibre Biopharmaceuticals, Cerevel Therapeutics, LLC, Neurona Therapeutics, Praxis Precision Medicines, UCB Pharma, Receptor Life Sciences, NeuroPro Therapeutics, Inc., Avicanna, Amring Pharmaceuticals Inc., Ovid Therapeutics, Addex Therapeutics, IAMA Therapeutics, CODA Biotherapeutics,  Cerebral Therapeutics, Engrail Therapeutics, and others.

Epilepsy Pipeline Analysis:

The Epilepsy pipeline report provides insights into 

• The report provides detailed insights about companies that are developing therapies for the treatment of Epilepsy with aggregate therapies developed by each company for the same.
• It accesses the Different therapeutic candidates segmented into early-stage, mid-stage, and late-stage of development for Epilepsy Treatment.
• Epilepsy key companies are involved in targeted therapeutics development with respective active and inactive (dormant or discontinued) projects.
• Epilepsy Drugs under development based on the stage of development, route of administration, target receptor, monotherapy or combination therapy, a different mechanism of action, and molecular type. 
• Detailed analysis of collaborations (company-company collaborations and company-academia collaborations), licensing agreement and financing details for future advancement of the Epilepsy market.

The report is built using data and information traced from the researcher’s proprietary databases, company/university websites, clinical trial registries, conferences, SEC filings, investor presentations, and featured press releases from company/university websites and industry-specific third-party sources, etc.

Download Sample PDF Report to know more about Epilepsy drugs and therapies

Epilepsy Pipeline Market Drivers

• Rising awareness and strategic alliance, increasing launch of novel drugs, high burden of epilepsy are some of the important factors that are fueling the Epilepsy Market.

Epilepsy Pipeline Market Barriers

• However, loss of patent protection for branded drugs, high cost of treatment and other factors are creating obstacles in the Epilepsy Market growth.

Scope of Epilepsy Pipeline Drug Insight    

• Coverage: Global
• Key Epilepsy Companies: Elium Therapeutics, CombiGene, Ovid Therapeutics, Otsuka Pharmaceutical Co.,Ltd., SK Biopharmaceutical, Receptor Life Sciences, Cerebral Therapeutics, Equilibre Biopharmaceutical, Cerevel Therapeutics, Engrail Therapeutics, Amzell, Xenon Pharmaceuticals Inc., Engage Therapeutics, Takeda Pharmaceuticals, GW Pharmaceuticals, Equilibre Biopharmaceuticals, Avicanna, and others
• Key Epilepsy Therapies: Kv7 Program, CG 01, OV329, OPC-214870, SKL24741, RLS103, CT-010, EQU 001, Darigabat, ENX-101, AMZ002, XEN496, Alprazolam inhalation, XEN1101, TAK-935, Cannabidivarin, EQU-001, AVCN-319302, and others
• Epilepsy Therapeutic Assessment: Epilepsy current marketed and Epilepsy emerging therapies
• Epilepsy Market Dynamics: Epilepsy market drivers and Epilepsy market barriers 

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Table of Contents 

1. Epilepsy Report Introduction

2. Epilepsy Executive Summary

3. Epilepsy Overview

4. Epilepsy- Analytical Perspective In-depth Commercial Assessment

5. Epilepsy Pipeline Therapeutics

6. Epilepsy Late Stage Products (Phase II/III)

7. Epilepsy Mid Stage Products (Phase II)

8. Epilepsy Early Stage Products (Phase I)

9. Epilepsy Preclinical Stage Products

10. Epilepsy Therapeutics Assessment

11. Epilepsy Inactive Products

12. Company-University Collaborations (Licensing/Partnering) Analysis

13. Epilepsy Key Companies

14. Epilepsy Key Products

15. Epilepsy Unmet Needs

16 . Epilepsy Market Drivers and Barriers

17. Epilepsy Future Perspectives and Conclusion

18. Epilepsy Analyst Views

19. Appendix

20. About DelveInsight

About DelveInsight

DelveInsight is a leading Business Consultant and Market Research firm focused exclusively on life sciences. It supports Pharma companies by providing comprehensive end-to-end solutions to improve their performance. It also offers Healthcare Consulting Services, which benefits in market analysis to accelerate business growth and overcome challenges with a practical approach.

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