DelveInsight’s “AL Amyloidosis Market Insights, Epidemiology, and Market Forecast 2032” report delivers an in-depth understanding of the disease, historical and forecasted epidemiology, as well as the AL Amyloidosis market size, share, trends, and growth opportunities in the seven major markets (7MM) (i.e., the United States, EU4 (Germany, Spain, Italy, France), the United Kingdom and Japan).
The report covers emerging AL Amyloidosis drugs, current treatment practices, market share of individual therapies, and current & forecasted market size from 2019 to 2032. It also evaluates the current AL Amyloidosis treatment practice/algorithm, key drivers & barriers impacting the market growth, and unmet medical needs to curate the best of the opportunities and assess the underlying potential of the market.
AL Amyloidosis: An Overview
Amyloidosis is a rare disease resulting from abnormal protein deposits, called amyloid, in various tissues of the body. Depending on the structure of the particular amyloid, the protein can accumulate in an isolated tissue or be widespread, affecting numerous organs and tissues. There are over 30 different amyloid proteins. Each amyloid protein is arranged in a structure called fibril-low molecular weight proteins derived from precursor proteins. Fibrils of amyloid can float in the plasma of blood and deposit into tissues of the body.
Amyloid light-chain (AL) amyloidosis, also known as primary amyloidosis, is the most common form of systemic amyloidosis. It starts in the bone marrow, the soft tissue inside the bones that makes blood-forming cells, including cells that create antibodies to fight infections. These cells can grow abnormally, causing an excess type of protein called light chains. If someone has AL amyloidosis, the light chains clump together and form amyloid deposits in their organs. Amyloid deposits can become so severe that they cause organ failure, which is when organs stop working effectively.
Treatment for AL amyloidosis is highly individualized, determined based on age, organ dysfunction, and regimen toxicities, and should be guided by biomarkers of hematologic and cardiac response. Alkylator-based chemotherapy is effective in almost two-thirds of patients. Novel agents are also active, and trials are ongoing to establish their optimal use. Some of the drugs in the pipeline include daratumumab (Janssen Pharmaceuticals), birtamimab (Prothena), CAEL-101 (AstraZeneca/Caelum Biosciences), melflufen (Oncopeptides AB), elotuzumab (Bristol-Myers Squibb), among others.
AL Amyloidosis Market Key Facts
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The total number of AL Amyloidosis Incident cases associated with 7MM countries was approximately 8,600 in 2021.
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AL amyloidosis is a rare disease, translating to 4,000 new cases per year in the US. This disease presents in older adults, median age of 64, with slight male predominance (54%).
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According to the Amyloidosis Foundation, AL amyloidosis is the most common type, with approximately 4,500 new cases diagnosed every year in the US.
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As per Ihne et al. (2020), AL amyloidosis is so far considered to be the most frequently occurring form with an incidence of 8.9–12.7 per million person-years in Germany.
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Among EU4 and the UK, Germany accounted for the highest total incident cases, whereas Spain accounted for the lowest number of cases in 2022.
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AL Amyloidosis is slightly more prominent in males as compared to females. The US had about 2,500 males compared to nearly 2,100 females suffering from AL Amyloidosis in 2022.
The market outlook section of the report helps to build a detailed comprehension of the historical, current, and forecasted market size by analyzing the impact of current and emerging AL Amyloidosis pipeline therapies. It also thoroughly assesses the AL Amyloidosis market drivers & barriers, unmet needs, and emerging technologies set to impact the market dynamics.
The report gives complete details of the market trend for each marketed AL Amyloidosis drug and mid & late-stage pipeline therapies by evaluating their impact based on the annual cost of therapy, their Mechanism of Action (MOA), Route of Administration (ROA), molecule types, competition with other therapies, brand value, and their impact on the market.
AL Amyloidosis Epidemiology Assessment
The epidemiology section provides insights into the historical, current, and forecasted AL Amyloidosis epidemiology trends in the seven major countries (7MM) from 2019 to 2032. It helps to recognize the causes of current and forecasted AL Amyloidosis epidemiology trends by exploring numerous studies and research. The epidemiology section also provides a detailed analysis of diagnosed and prevalent patient pools, future trends, and views of key opinion leaders.
The Report Covers the AL Amyloidosis Epidemiology, Segmented as –
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Total AL Amyloidosis Incident cases
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AL Amyloidosis Gender-Specific Cases
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AL Amyloidosis Age-specific Cases
AL Amyloidosis Drugs Uptake and Pipeline Development Activities
The drug uptake section focuses on the uptake rate of potential drugs recently launched in the AL Amyloidosis market or expected to be launched during the study period. The analysis covers the AL Amyloidosis market uptake by drugs, patient uptake by therapies, and sales of each drug. Moreover, the therapeutics assessment section helps understand the market dynamics by drug sales, the most rapid drug uptake, and the reasons behind the maximal use of particular drugs. Additionally, it compares the AL Amyloidosis drugs based on their sale and market share.
The report also covers the AL Amyloidosis pipeline development activities. It provides valuable insights about different therapeutic candidates in various stages and the key AL Amyloidosis companies involved in developing targeted therapeutics. It also analyzes recent developments such as collaborations, acquisitions, mergers, licensing patent details, and other information for emerging therapies.
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AL Amyloidosis Therapeutics Analysis
The goal of treatment is to rapidly reduce the plasma cell clone to rescue organ function by improving the reabsorption of amyloid deposits to rapidly ameliorate cardiac function to improve patients’ QOL and survival. The suppression of amyloid light chain synthesis is effectively achieved using chemotherapy (both conventional and high dose) in combination with autologous hematopoietic stem cell transplantation (ASCT) in the eligible patients. Among patients who are ineligible for ASCT, melphalan, dexamethasone, and bortezomib-based regimens are recommended. High-dose melphalan followed by ASCT is one treatment option included in the National Comprehensive Cancer Network guidelines.
AL Amyloidosis Companies Actively Working in the Therapeutics Market Include
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Caelum Biosciences
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Nexcella, Inc.
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HaemaLogiX Ltd.
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Prothena
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ZENTALIS PHARMACEUTICALS
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Sorrento Therapeutics, Inc.
And Many Others
Emerging and Marketed AL Amyloidosis Therapies Covered in the Report Include:
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CAEL-101: Caelum Biosciences
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NXC-201: Nexcella, Inc.
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Daratumumab: Janssen Pharmaceutical/Genmab
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Birtamimab: Prothena
And Many More
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Table of Content (TOC)
1. Key Insights
2. Executive Summary
3. AL Amyloidosis Competitive Intelligence Analysis
4. AL Amyloidosis Market Overview at a Glance
5. AL Amyloidosis Disease Background and Overview
6. AL Amyloidosis Patient Journey
7. AL Amyloidosis Patient Population and Epidemiology Trends (In the US, EU5, and Japan)
8. AL Amyloidosis Treatment Algorithm, Current Treatment, and Medical Practices
9. AL Amyloidosis Unmet Needs
10. Key Endpoints of AL Amyloidosis Treatment
11. AL Amyloidosis Marketed Therapies
12. AL Amyloidosis Emerging Drugs and Latest Therapeutic Advances
13. AL Amyloidosis Seven Major Market Analysis
14. Attribute Analysis
15. AL Amyloidosis Market Outlook (In US, EU5, and Japan)
16. AL Amyloidosis Companies Active in the Market
17. AL Amyloidosis Access and Reimbursement Overview
18. KOL Views on the AL Amyloidosis Market
19. AL Amyloidosis Market Drivers
20. AL Amyloidosis Market Barriers
21. Appendix
22. DelveInsight Capabilities
23. Disclaimer
*The Table of Contents (TOC) is not exhaustive; the final content may vary. Refer to the sample report for the complete table of contents.
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About DelveInsight
DelveInsight is a leading Business Consultant and Market Research Firm focused exclusively on life sciences. It supports pharma companies by providing comprehensive end-to-end solutions to improve their performance.
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