(Albany, USA) CD47 Inhibitors Market Insights report by DelveInsight includes a comprehensive understanding of current treatment practices, emerging CD47 inhibitors, market share of individual therapies, and current and forecasted CD47 inhibitors market size from 2020 to 2034, segmented into 7MM [the United States, the EU4 (Germany, France, Italy, and Spain), the United Kingdom, and Japan].
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Some facts of the CD47 Inhibitors Market Report
- As per DelveInsight’s analysis, the total CD47 inhibitors market size of in the 7MM is expected to surge significantly by 2034.
- Leading CD47 inhibitor companies such as ALX Oncology, Phanes Therapeutics, Pfizer, Akeso Biopharma, ImmuneOnco Biopharma, and others are developing novel CD47 inhibitors that can be available in the CD47 inhibitors market in the coming years.
- Some of the key CD47 inhibitors in the pipeline include Evorpacept + Herceptin + Cyramza + Paclitaxel, Evorpacept + Pembrolizumab, PT217, maplirpacept (TTI-622), ligufalimab (AK117), IMM01, and others.
- In June 2024, SL-172154 received FDA Orphan Drug Designation in Acute Myeloid Leukemia. SL-172154 is an investigational activity-regulated cytoskeleton-associated protein (ARC) fusion protein that inhibits the checkpoint interaction of CD47/SIRPα and activates the CD40 costimulatory receptor. The agent is designed to boost the antitumor immune response in patients with advanced cancer.
- In July 2022, the FDA granted Orphan Drug Designation to Evorpacept for Acute Myeloid Leukemia, and in August 2022, Fast Track Designation for Head and Neck Squamous Cell Carcinoma.
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CD47 Inhibitors Market Dynamics
The CD47 inhibitors market is evolving rapidly as these novel therapies gain attention in oncology for their ability to block the “don’t eat me” signal used by cancer cells, thereby boosting the immune system’s capacity to eliminate tumors. A key factor driving market growth is the robust pipeline of investigational drugs, with numerous biotech and pharmaceutical companies developing CD47-targeting therapies. Several candidates, including monoclonal antibodies and small molecules, are in various clinical trial stages, aimed at disrupting the interaction between CD47 on cancer cells and SIRPα on macrophages. The progress of these trials is generating significant interest and anticipation within the market.
However, the CD47 inhibitors market faces challenges. One major issue is ensuring selective targeting of cancer cells without impacting normal cells, as CD47 is widely expressed across tissues. Additionally, concerns about side effects, such as anemia due to CD47’s role in red blood cell regulation, and regulatory hurdles related to clinical validation pose further obstacles. Companies must demonstrate both efficacy and safety before gaining market approval.
The competitive landscape is also dynamic, with major pharmaceutical companies competing through strategic collaborations, mergers, and acquisitions to expand their CD47-targeting portfolios. As leading candidates near late-stage trials and commercialization, the market is expected to shift rapidly, potentially giving rise to blockbuster drugs.
CD47 Inhibitors Treatment Market
Therapies targeting CD47, such as antibody-based treatments, CAR T-cell therapy, and combination approaches, have demonstrated the potential to boost anti-tumor immunity and enhance clinical outcomes. CD47-targeted immunotherapies work by disrupting the “don’t eat me” signal between CD47 on cancer cells and SIRPα on myeloid cells. This disruption is often achieved using blocking antibodies or small molecules that inhibit this interaction, leading to increased phagocytosis of cancer cells by macrophages and stimulating an anti-tumor immune response. Preclinical studies and early-stage clinical trials have yielded promising results with CD47 inhibitors across various cancer types, including leukemia, lymphoma, breast cancer, and others.
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Key CD47 Inhibitors Companies
Several key players, including ALX Oncology, Phanes Therapeutics, Shattuck Labs, and others, are involved in developing drugs for CD47 inhibitors for various indications such as gastric/gastroesophageal junction cancer, head and neck cancer, small cell lung cancer, and others.
The anticipated launch of these emerging therapies are poised to transform the CD47 inhibitors market landscape in the coming years. As these cutting-edge therapies continue to mature and gain regulatory approval, they are expected to reshape the CD47 inhibitors market landscape, offering new standards of care and unlocking opportunities for medical innovation and economic growth.
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CD47 Inhibitors Overview
CD47 inhibitors are an emerging class of cancer therapies designed to block the “don’t eat me” signal that cancer cells use to evade the immune system. CD47 is a protein expressed on the surface of many cells, including cancer cells, and it interacts with SIRPα receptors on macrophages, preventing them from engulfing and destroying the cancer cells. By inhibiting this interaction, CD47 inhibitors enable macrophages to recognize and eliminate cancer cells more effectively.
These therapies have garnered significant attention in oncology due to their potential to enhance the body’s natural immune response to tumors. CD47 inhibitors are being developed in the form of monoclonal antibodies and small molecules, and many candidates are currently in clinical trials targeting a range of cancers, including leukemia, lymphoma, and solid tumors.
Despite their promise, CD47 inhibitors face challenges, such as ensuring selective targeting of cancer cells without affecting healthy cells, since CD47 is also present on normal cells. Additionally, potential side effects like anemia, linked to CD47’s role in red blood cell regulation, are concerns. However, with ongoing research and clinical trials, CD47 inhibitors hold great potential as a new approach to cancer treatment, with several promising candidates advancing toward commercialization.
CD47 Inhibitors Epidemiology Segmentation
The CD47 inhibitors market report proffers epidemiological analysis for the study period 2020–2034 in the 7MM segmented into:
- Total Prevalent Cases in Selected Indications for CD47 Inhibitors
- Total Eligible Patient Pool for CD47 Inhibitors in Selected Indications
- Total Treated Cases in Selected Indications for CD47 Inhibitors
Scope of the CD47 Inhibitors Market Report
- Study Period: 2020–2034
- CD47 Inhibitors Report Coverage: 7MM [The United States, the EU-4 (Germany, France, Italy, and Spain), the United Kingdom, and Japan]
- Key CD47 Inhibitors Companies: ALX Oncology, Phanes Therapeutics, Pfizer, Akeso Biopharma, ImmuneOnco Biopharma, and others
- Key CD47 Inhibitors: Evorpacept + Herceptin + Cyramza + Paclitaxel, Evorpacept + Pembrolizumab, PT217, maplirpacept (TTI-622), ligufalimab (AK117), IMM01, and others
- CD47 Inhibitors Therapeutic Assessment: CD47 Inhibitors current marketed and emerging therapies
- CD47 Inhibitors Market Dynamics: Conjoint Analysis of Emerging CD47 Inhibitors Drugs
- Competitive Intelligence Analysis: SWOT analysis and Market entry strategies
- Unmet Needs, KOL’s views, Analyst’s views, CD47 Inhibitors Market Access and Reimbursement
Discover more about CD47 inhibitors in development @ CD47 Inhibitors Clinical Trials
Table of Contents
1. Key Insights
2. Report Introduction
3. Executive Summary of CD47 Inhibitors
4. Key Events
5. Market Forecast Methodology
6. CD47 Inhibitors Market Overview at a Glance in the 7MM
6.1. Market Share (%) Distribution by Indication in 2020
6.2. Market Share (%) Distribution by Indication in 2034
7. CD47 Inhibitors: Background and Overview
7.1. Introduction
7.2. Evolution of CD47 Inhibitors
7.3. Treatment
8. Target Patient Pool
8.1. Key Findings
8.2. Assumptions and Rationale: 7MM
8.3. Epidemiology Scenario in the 7MM
8.3.1. Total Prevalent Cases in Selected Indications for CD47 Inhibitors in the 7MM
8.3.2. Total Eligible Patient Pool for CD47 Inhibitors in Selected Indications in the 7MM
8.3.3. Total Treated Cases in Selected Indications for CD47 Inhibitors in the 7MM
8.4. Epidemiology Scenario in the US
8.4.1. Total Prevalent Cases in Selected Indications for CD47 Inhibitors in the US
8.4.2. Total Eligible Patient Pool for CD47 Inhibitors in Selected Indications in the US
8.4.3. Total Treated Cases in Selected Indications for CD47 Inhibitors in the US
8.5. Epidemiology Scenario in EU4 and the UK
8.5.1. Total Prevalent Cases in Selected Indications for CD47 Inhibitors in EU4 and the UK
8.5.2. Total Eligible Patient Pool for CD47 Inhibitors in Selected Indications in EU4 and the UK
8.5.3. Total Treated Cases in Selected Indications for CD47 Inhibitors in EU4 and the UK
8.6. Epidemiology Scenario in Japan
8.6.1. Total Prevalent Cases in Selected Indications for CD47 Inhibitors in Japan
8.6.2. Total Eligible Patient Pool for CD47 Inhibitors in Selected Indications in Japan
8.6.3. Total Treated Cases in Selected Indications for CD47 Inhibitors in Japan
9. Emerging Therapies
9.1. Key Competitors
9.2. Evorpacept (ALX148): ALX Oncology
9.2.1. Product Description
9.2.2. Other developmental activities
9.2.3. Clinical development
9.2.4. Safety and efficacy
9.3. PT217: Phanes Therapeutics
9.3.1. Product Description
9.3.2. Other developmental activities
9.3.3. Clinical development
9.3.4. Safety and efficacy
List to be continued in the report
10. CD47 Inhibitor: Seven Major Market Analysis
10.1. Key Findings
10.2. Market Outlook
10.3. Key Market Forecast Assumptions
10.4. Total Market Size of CD47 inhibitors in the 7MM
10.5. Market Size of CD47 Inhibitors by Indication in the7MM
10.6. The United States Market Size
10.6.1. Total Market Size of CD47 Inhibitors in the United States
10.6.2. Market Size of CD47 Inhibitors by Indication in the United States
10.6.3. Market Size of CD47 Inhibitors by Therapies in the United States
10.7. EU4 and the UK Market Size
10.7.1. Total Market Size of CD47 Inhibitors in EU4 and the UK
10.7.2. Market Size of CD47 Inhibitors by Indication in EU4 and the UK
10.7.3. Market Size of CD47 Inhibitors by Therapies in EU4 and the UK
10.8. Japan Market Size
10.8.1. Total Market Size of CD47 Inhibitors in Japan
10.8.2. Market Size of CD47 Inhibitors by Indication in Japan
10.8.3. Market Size of CD47 Inhibitors by Therapies in Japan
11. Market Access and Reimbursement
12. SWOT Analysis
13. KOL Views
14. Unmet Needs
15. Appendix
15.1. Bibliography
15.2. Report Methodology
16. DelveInsight Capabilities
17. Disclaimer
18. About DelveInsight
About DelveInsight
DelveInsight is a leading Business Consultant and Market Research firm focused exclusively on life sciences. It supports Pharma companies by providing comprehensive end-to-end solutions to improve their performance. It also offers Healthcare Consulting Services, which benefits in market analysis to accelerate business growth and overcome challenges with a practical approach.
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