New York – September 29th, 2018 – Creative Biogene, world’s top biotechnology services and products provider since 2005, has announced the significant release of its powerful screening service – ion channel screening service by generating an extensive panel of ion channel screening assays comprising a wide range of binding and functional assays, such as TRP ion channel family, ion channel assays etc. With this professional offer, Creative Biogene intends to better understand the demands of customers and quickly and accurately provide results for drug discovery.
Ion Channel, as a membrane protein complex, which function is to promote the diffusion of ions on the biofilm. It provides a highly conductive hydrophilic pathway through the hydrophobic interior of the membrane, meanwhile, acting as gateways that allow ions to pass through them in response to multiple signal events. And they are approved for regulating various processes that are important for ion homeostasis.
As a key component of various biological processes involved in rapid cell changes, ion channels are an important therapeutic target for a range of indications, including the heart, CNS, immune system, and metabolic diseases. With the development of screening techniques, significantly increased interest in hit verification, potency assay, selectivity analysis, and lead optimization has been shown in ion channels. The major applications of ion channel including but not limited to: explore the interaction between compounds and specific ion channels, study the pathogenesis and treatment of arrhythmia, multiple sclerosis, and obesity, screening for the activity of drugs acting on ion channels during drug discovery etc.
In order to obtain more specific biophysical and pharmacological analyses, scientists have simplified ion channels by expressing ion channels in cultured non-neural cell lines. Creative Biogene has developed the broadest collection of the cell line that can stably express functional ion channels, besides, the potential for ion channel potency, efficacy, specificity or off-target effects of compounds can also be high-throughput identified in early drug discovery by processing a large pool of ion channels expressed from mammalian cells.
‘Our experienced scientists will provide researchers with a wide range of optimized and validated ion channel stable cell lines for your electrophysiological experiments. In addition, off-the-shelf or customized assays are available for screening and analyzing ion channel targets.’ Said Wendy Wilson, the marketing director of Creative Biogene, ‘More than a decade of experience in the field has enabled us to reduce risk and maximize the success rate of your discovery program. Our flexible service allows any single channel or combination of channels to be tested as part of a custom panel. In addition, we can also provide customized solutions for your specified concentration range and assay protocol.’
About Creative Biogene
Founded in 2005, Creative Biogene provides researchers with innovative biotechnology technologies for research discoveries and product development, futhermore, help researchers explore the areas about gene discovery, regulation, and function. Creative Biogene is a well-recognized industry leader with more than 10 years experiences and million customers worldwide.
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