(Albany, USA) DelveInsight’s “Critical Limb Ischemia Market Insights, Epidemiology, and Market Forecast-2034” report delivers an in-depth understanding of Critical Limb Ischemia, historical and forecasted epidemiology as well as the Critical Limb Ischemia market trends in the United States, EU5 (Germany, Spain, Italy, France, and United Kingdom), and Japan.
The Critical Limb Ischemia market report provides current treatment practices, emerging drugs, the market share of the individual therapies, and the current and forecasted Critical Limb Ischemia market size from 2020 to 2034, segmented by seven major markets. The Report also covers current Critical Limb Ischemia treatment practice/algorithm, market drivers, market barriers, and unmet medical needs to curate the best opportunities and assesses the underlying potential of the Critical Limb Ischemia market.
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Some facts of the Critical Limb Ischemia Market Report are:
- According to DelveInsight, the Critical Limb Ischemia market size in USA was USD 1,367 million in 2023.
- Leading Critical Limb Ischemia companies working in the market are Boston Scientific Corporation, AnGes, Inc., Mitsubishi Tanabe Pharma, B. Braun Melsungen AG, Medtronic Endovascular, Ixaka Ltd (formerly Rexgenero), Mercator MedSystems, Inc, Hemostemix Inc., Caladrius Biosciences, Reven Pharmaceuticals, Inc., New Beta Innovation Limited, BioGenCell Ltd., Abbott Medical Devices and others.
- Key Critical Limb Ischemia Therapies expected to launch in the market are REX-001, Temsirolimus Adventitial Delivery, Collategene, ACP-01, Honedra (CLBS12), RJX (Rejuveinix), YQ23, BGC101, Esprit BTK Device, and others.
- As of June 2024, AnGes has drawn the manufacturing and marketing approval application that was to be refiled after the conditional and time-limited marketing approval. The expiration date of the current conditional and time-limited marketing approval is expired, and the distribution of Collategene is also discontinued.
- In April 2024, Allife Medical Science and Technology Co., Ltd announced results of a Phase I Clinical Study on the Safety and Preliminary Efficacy of Allogeneic Endothelial Progenitor Cells (EPCs) Injection in Patients With Critical Limb Ischemia
- In February 2024, Cell Biopeutics Resources Sdn Bhd announced results of an Observational, Practice-Based, Open Label, Feasibility Study to Observe the Efficacy and Safety of Intramuscular Administration of Stempeucel® in Malaysian Patients With Critical Limb Ischemia (CLI) Due to Peripheral Arterial Disease.
Critical Limb Ischemia Overview
Critical limb ischemia is a clinical syndrome characterized by ischemic pain at rest and tissue loss, such as nonhealing ulcers or gangrene, caused by lower limb peripheral arterial disease (PAD). Critical limb ischemia is the final stage of PAD, and macrovascular lesions cause a decrease in distal perfusion. This disease drastically impairs nutrient blood flow to tissues and microcirculation exchange.
Rutherford has traditionally characterized critical limb ischemia as rest pain (class 4), tissue loss (class 5), and gangrene (class 6). Rest discomfort is classified as class 3 in the Fontaine classification, and tissue loss or gangrene is classified as class 4 in the Fontaine classification. The threatened critical limb ischemia classification system was recently developed by the Society for Vascular Surgery Lower Extremity Guidelines Committee: Risk stratification based on wound, ischemia, and foot infection (WIfI).
The critical limb ischemia life expectancy is around 1.23 years for men and 2.7 years for women.
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Critical Limb Ischemia Market
Critical Limb Ischemia (CLI) represents a significant challenge in healthcare due to its potential for severe complications such as amputation and mortality. The market dynamics surrounding CLI have been evolving as a result of various factors. One key driver is the increasing prevalence of diabetes and vascular diseases, which are major risk factors for CLI. The aging population in many parts of the world also contributes to the rising incidence of CLI, creating a larger patient pool in need of treatment.
Additionally, advancements in medical technology have spurred market growth, with the development of innovative therapies such as drug-eluting stents, bioresorbable stents, and minimally invasive procedures. These technologies offer more effective and less invasive treatment options for CLI patients, driving demand in the market. Moreover, there has been a growing focus on early diagnosis and intervention, leading to increased awareness among healthcare professionals and patients alike. This shift towards proactive CLI management is expected to further fuel market expansion as it reduces the overall healthcare burden associated with advanced stages of the disease, improving patient outcomes and quality of life.
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Critical Limb Ischemia Treatment Market
Management of CLI often involves a multifaceted approach, with the primary goal of restoring blood flow to the affected limb. This typically begins with lifestyle modifications such as smoking cessation and maintaining a healthy diet. Medications, such as antiplatelet agents and anticoagulants, are commonly prescribed to reduce blood clotting and improve circulation. Additionally, minimally invasive procedures like angioplasty and stenting can be utilized to open blocked arteries and enhance blood flow. In more advanced cases, surgical options such as bypass grafting may be necessary to reroute blood around the blockage, thereby salvaging the limb.
Close monitoring and follow-up care are integral aspects of CLI treatment, as the condition requires ongoing management to prevent recurrence and monitor for potential complications. Patients often undergo rehabilitation programs to improve mobility and reduce the risk of further vascular issues. In severe instances where limb preservation is not feasible, amputation may be considered as a last resort. Through a combination of medical therapies, interventions, and lifestyle adjustments, clinicians strive to improve quality of life, enhance limb function, and mitigate the serious consequences associated with Critical Limb Ischemia.
Critical Limb Ischemia Epidemiology
The Critical Limb Ischemia epidemiology section provides insights into the historical and current Critical Limb Ischemia patient pool and forecasted trends for seven individual major countries. It helps to recognize the causes of current and forecasted trends by exploring numerous studies and views of key opinion leaders. This part of the Critical Limb Ischemia market report also provides the diagnosed patient pool, trends, and assumptions.
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Critical Limb Ischemia Drugs Uptake
This section focuses on the uptake rate of the potential Critical Limb Ischemia drugs recently launched in the Critical Limb Ischemia market or expected to be launched in 2020-2034. The analysis covers the Critical Limb Ischemia market uptake by drugs, patient uptake by therapies, and sales of each drug.
Critical Limb Ischemia Drugs Uptake helps in understanding the drugs with the most rapid uptake and the reasons behind the maximal use of new drugs and allows the comparison of the drugs based on Critical Limb Ischemia market share and size, which again will be useful in investigating factors important in market uptake and in making financial and regulatory decisions.
Critical Limb Ischemia Pipeline Development Activities
The Critical Limb Ischemia report provides insights into different therapeutic candidates in Phase II, and Phase III stages. It also analyses Critical Limb Ischemia key players involved in developing targeted therapeutics.
Critical Limb Ischemia Therapeutics Assessment
Major key companies are working proactively in the Critical Limb Ischemia Therapeutics market to develop novel therapies which will drive the Critical Limb Ischemia treatment markets in the upcoming years are Boston Scientific Corporation, AnGes, Inc., Mitsubishi Tanabe Pharma, B. Braun Melsungen AG, Medtronic Endovascular, Ixaka Ltd (formerly Rexgenero), Mercator MedSystems, Inc, Hemostemix Inc., Caladrius Biosciences, Reven Pharmaceuticals, Inc., New Beta Innovation Limited, BioGenCell Ltd., Abbott Medical Devices and others.
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Critical Limb Ischemia Report Key Insights
1. Critical Limb Ischemia Patient Population
2. Critical Limb Ischemia Market Size and Trends
3. Key Cross Competition in the Critical Limb Ischemia Market
4. Critical Limb Ischemia Market Dynamics (Key Drivers and Barriers)
5. Critical Limb Ischemia Market Opportunities
6. Critical Limb Ischemia Therapeutic Approaches
7. Critical Limb Ischemia Pipeline Analysis
8. Critical Limb Ischemia Current Treatment Practices/Algorithm
9. Impact of Emerging Therapies on the Critical Limb Ischemia Market
Table of Contents
1. Key Insights
2. Executive Summary
3. Critical Limb Ischemia Competitive Intelligence Analysis
4. Critical Limb Ischemia Market Overview at a Glance
5. Critical Limb Ischemia Disease Background and Overview
6. Critical Limb Ischemia Patient Journey
7. Critical Limb Ischemia Epidemiology and Patient Population
8. Critical Limb Ischemia Treatment Algorithm, Current Treatment, and Medical Practices
9. Critical Limb Ischemia Unmet Needs
10. Key Endpoints of Critical Limb Ischemia Treatment
11. Critical Limb Ischemia Marketed Products
12. Critical Limb Ischemia Emerging Therapies
13. Critical Limb Ischemia Seven Major Market Analysis
14. Attribute Analysis
15. Critical Limb Ischemia Market Outlook (7 major markets)
16. Critical Limb Ischemia Access and Reimbursement Overview
17. KOL Views on the Critical Limb Ischemia Market
18. Critical Limb Ischemia Market Drivers
19. Critical Limb Ischemia Market Barriers
20. Appendix
21. DelveInsight Capabilities
22. Disclaimer
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