(Albany, USA) DelveInsight’s Diabetic Kidney Disease Market Insights report includes a comprehensive understanding of current treatment practices, diabetic kidney disease emerging drugs, market share of individual therapies, and current and forecasted market size from 2020 to 2034, segmented into 7MM [the United States, the EU4 (Germany, France, Italy, and Spain), the United Kingdom, and Japan].
Key Takeaways from the Diabetic Kidney Disease Market Report
- According to DelveInsight’s analysis, the market size for diabetic kidney disease reached USD 7.2 billion in 2023 across the 7MM and is expected to grow with a significant CAGR by 2034.
- DelveInsight’s analysis reveals that the overall prevalent population of diabetic kidney disease in the 7MM was reported as ~33 million in 2023.
- Leading diabetic kidney disease companies such as Boehringer Ingelheim, Daiichi Sankyo, ProKidney, Chinook Therapeutics (a Novartis company), AbbVie, Inversago Pharma (a Novo Nordisk Company), Mineralys Therapeutics, CSL Behring, Teijin Pharma, Dimerix, Chugai Pharmaceutical, Lisata Therapeutics and others are developing novel diabetic kidney disease drugs that can be available in the diabetic kidney disease market in the coming years.
- The promising diabetic kidney disease therapies in the pipeline include Esaxerenone (CS-3150), REACT (Renal Autologous Cell Therapy), Zibotentan + dapagliflozin, BI 690517 ± empagliflozin, Atrasentan, Tozorakimab (MEDI3506) + dapagliflozin, INV-202, and others.
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Diabetic Kidney Disease Overview
Diabetic kidney disease (DKD), also referred to as diabetic nephropathy (DN), is a clinical condition marked by persistent albuminuria and a gradual decline in renal function. This term implies the existence of a recognizable pattern of glomerular disease. Typically, Diabetic Kidney Disease is linked with high blood pressure, leading to increased cardiovascular risks and mortality. The causes of DKD are intricate and likely involve various factors, with hyperglycemia being the primary contributor. Initial stages of Diabetic Kidney Disease may be asymptomatic, but as renal function diminishes, the accumulation of toxic wastes can lead to symptoms such as nausea, vomiting, loss of appetite, hiccups, and weight gain due to fluid retention. Untreated cases may progress to heart failure and pulmonary edema.
Detecting and diagnosing Diabetic Kidney Disease poses challenges. Screening and renal biopsy are the main diagnostic methods used to identify Diabetic Kidney Disease in patients. In instances of nonalbuminuric DKD, other potential diagnoses considered include ischemic nephropathy, dysproteinemia, and tubulointerstitial nephritis (TIN).
Diabetic Kidney Disease Epidemiology Segmentation
Among the 7MM, the United States accounted for the highest number of diagnosed prevalent cases of DKD, i.e., ~45% of the total cases in the 7MM in 2023.
Among EU4 and the UK, Germany accounted for the largest number of DKD cases, whereas France accounted for the lowest number of cases in 2023.
The diabetic kidney disease market report proffers epidemiological analysis for the study period 2020–2034 in the 7MM segmented into:
- Total Prevalent Cases of Diabetes
- Total Prevalent Cases of Diabetic Kidney Disease
- Total Diagnosed Prevalent Cases of Diabetic Kidney Disease
- Age-specific Cases of Diabetic Kidney Disease
- Stage-specific Cases of Diabetic Kidney Disease
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Diabetic Kidney Disease Treatment Market
The primary approach to treating DKD involves the reduction of blood pressure, as even a slight elevation in blood pressure can rapidly exacerbate kidney disease. Additionally, it is crucial to manage blood sugar levels to decelerate the progression of diabetic nephropathy. Fundamental methods for lowering blood pressure encompass weight loss, reduced salt intake, abstaining from alcohol and tobacco, and engaging in regular exercise.
The preferred medications for blood pressure management often include angiotensin-converting enzyme (ACE) inhibitors. Capoten (captopril), unlike many ACE inhibitors, is not a prodrug. It competes with AT-I for ACE binding, hindering the enzymatic breakdown of angiotensin I (AT-I) into angiotensin II (AT-II), consequently heightening plasma renin activity. Another medication, enalapril, is an inactive prodrug that undergoes hepatic transformation to generate enalaprilat, its active form. Enalaprilat acts on the Renin-Angiotensin-Aldosterone System (RAAS) to impede ACE, leading to the suppression of RAAS and exhibiting antihypertensive effects in individuals with low-renin hypertension.
In September 2019, the US Food and Drug Administration (FDA) approved the first therapeutic drug designed to treat DKD, INVOKANA (canagliflozin). This medication, categorized as a sodium-glucose co-transporter 2 (SGLT2) inhibitor, plays a crucial role in the majority of glucose reabsorption from the tubular lumen. Canagliflozin inhibits SGLT2, resulting in a decrease in the reabsorption of filtered glucose, a reduction in the renal threshold for glucose (RTG), and consequently, an increase in urinary glucose excretion (UGE). Furthermore, in August 2019, the European Medicines Agency (EMA) accepted the submission for the extension of its license.
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Diabetic Kidney Disease Pipeline Therapies and Key Companies
- MINNEBRO (ESAXERENONE/CS-3150): DAIICHI SANKYO
- REACT (RENAL AUTOLOGOUS CELL THERAPY): PROKIDNEY
- ZIBOTENTAN + DAPAGLIFLOZIN: ASTRAZENECA
- VYLEESI (BREMELANOTIDE): PALATIN
- TOZORAKIMAB (MEDI3506) + DAPAGLIFLOZIN: ASTRAZENECA
- ATRASENTAN: CHINOOK THERAPEUTICS/NOVARTIS
- LORUNDROSTAT: MINERALYS THERAPEUTICS
- BI 690517 + EMPAGLIFLOZIN: BOEHRINGER INGELHEIM
- INV-202: INVERSAGO PHARMA
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Diabetic Kidney Disease Market Dynamics
The dynamics of the DKD market are expected to change in the coming years. The global rise in diabetes prevalence has contributed significantly to the surge in DKD cases, creating a substantial patient population in need of effective treatments. As awareness about the complications associated with diabetes, including kidney disease, increases, there is a growing demand for therapeutic interventions that specifically target DKD. Additionally, advancements in diagnostic technologies enable earlier and more accurate detection of kidney disease in diabetic patients, fostering a proactive approach to management.
Furthermore, many potential therapies are being investigated for the treatment of DKD, and it is safe to predict that the treatment space will significantly impact the DKD market during the forecast period. Moreover, the anticipated introduction of emerging therapies with improved efficacy and a further improvement in the diagnosis rate are expected to drive the growth of the diabetic kidney disease market in the 7MM.
However several factors may impede the growth of the DKD market. One of the primary challenges is the complexity of the disease itself. DKD is intricately linked to diabetes, a condition with multifaceted causes and manifestations. This complexity makes it challenging to develop targeted and effective treatments.
Moreover, DKD treatment poses a significant economic burden and disrupts patients’ overall well-being and QOL. Furthermore, the DKD market growth may be offset by failures and discontinuation of emerging therapies. In addition, the undiagnosed, unreported cases and the unawareness about the disease may also impact the Diabetic Kidney Disease market growth.
A deeper understanding of the molecular mechanisms of DKD onset and progression is necessary for the development of new and innovative treatments for DKD. Furthermore, as DKD often goes undiagnosed due to its initial lack of symptoms, the use of advanced predictive tests for early detection can augment physicians’ capacity to make well-informed treatment decisions. This, in turn, can result in improved clinical outcomes and streamline more effective therapeutic interventions.
Scope of the Diabetic Kidney Disease Market Report
- Study Period: 2020–2034
- Coverage: 7MM [the United States, the EU4 (Germany, France, Italy, and Spain), the United Kingdom, and Japan].
- Diabetic Kidney Disease Market CAGR (2020–2034): 6.5 %
- Diabetic Kidney Disease Market Size in 2023: USD 7.2 Billion
- Key Diabetic Kidney Disease Companies: Johnson & Johnson, Mitsubishi Tanabe Pharma, AstraZeneca, Bayer, Boehringer Ingelheim, Eli Lilly, Daiichi Sankyo, ProKidney, Chinook Therapeutics (a Novartis company), AbbVie, Inversago Pharma (a Novo Nordisk Company), Mineralys Therapeutics, CSL Behring, Teijin Pharma, Dimerix, Chugai Pharmaceutical, Lisata Therapeutics and others
- Key Pipeline Diabetic Kidney Disease Therapies: MINNEBRO (ESAXERENONE/CS-3150), REACT (RENAL AUTOLOGOUS CELL THERAPY), ZIBOTENTAN + DAPAGLIFLOZIN, VYLEESI (BREMELANOTIDE), TOZORAKIMAB (MEDI3506) + DAPAGLIFLOZIN, ATRASENTAN, LORUNDROSTAT, BI 690517 + EMPAGLIFLOZIN, INV-202, and others
- Therapeutic Assessment: Diabetic Kidney Disease current marketed and emerging therapies
- Diabetic Kidney Disease Market Dynamics: Key Market Forecast Assumptions of Emerging Diabetic Kidney Disease Drugs, Conjoint Analysis and Market Outlook
- Competitive Intelligence Analysis: SWOT analysis and Market entry strategies
- Unmet Needs, KOL’s views, Analyst’s views, Diabetic Kidney Disease Market Access and Reimbursement
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Table of Contents
1. Diabetic Kidney Disease Key Insights
2. Diabetic Kidney Disease Report Introduction
3. Diabetic Kidney Disease Overview at a Glance
4. Diabetic Kidney Disease Executive Summary
5. Diabetic Kidney Disease Key Events
6. Epidemiology and Market Forecast Methodology
7. Disease Background and Overview
8. Diabetic Kidney Disease Treatment and Management
9. Diabetic Kidney Disease Guidelines
10. Diabetic Kidney Disease Epidemiology and Patient Population
11. Patient Journey
12. Key Endpoints in Diabetic Kidney Disease
13. Diabetic Kidney Disease Marketed Drugs
14. Diabetic Kidney Disease Emerging Drugs
15. 7MM Diabetic Kidney Disease Market Analysis
16. Market Access and Reimbursement
17. KOL Views
18. Unmet Needs
19. SWOT Analysis
20. Appendix
21. DelveInsight Capabilities
22. Disclaimer
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