Several major pharma and biotech companies such as Fulcrum Therapeutics, Roche, and others are persistently working towards the development of new treatment therapies for FSHD. The launch of the pipeline therapies is expected to immensely transform the treatment scenario in the coming years.
DelveInsight’s “Facioscapulohumeral Muscular Dystrophy (FSHD) Market Insights, Epidemiology, and Market Forecast 2032” report delivers an in-depth understanding of the disease, historical and forecasted epidemiology, as well as the Facioscapulohumeral Muscular Dystrophy market size, share, trends, and growth opportunities in the seven major markets (7MM) (i.e., the United States, EU4 (Germany, Spain, Italy, France), the United Kingdom and Japan).
The report covers emerging Facioscapulohumeral Muscular Dystrophy drugs, current treatment practices, market share of individual therapies, and current & forecasted market size from 2019 to 2032. It also evaluates the current Facioscapulohumeral Muscular Dystrophy treatment practice/algorithm, key drivers & barriers impacting the market growth, and unmet medical needs to curate the best of the opportunities and assess the underlying potential of the market.
Facioscapulohumeral Muscular Dystrophy (FSHD): An Overview
Facioscapulohumeral Muscular Dystrophy (FSHD), also known as Landouzy-Dejerine muscular dystrophy, is a disorder characterized by muscle weakness and wasting (atrophy). The disorder gets its name from muscles that are affected in the face (facio), around the shoulder blades (scapulo), and in the upper arms (humeral). Hamstring and trunk muscles are affected -early on but are less well recognized. Other arm and leg muscles are frequently eventually affected in the course of the disease. Symptoms usually appear before age 20 but can begin in infancy or later in adulthood.
FSHD is a genetically acquired disease that leads to progressive muscle weakness and severely decreased functional capacity in affected individuals—understanding how epigenetic factors interplay has evolved substantially in recent years. FSHD can be classified into two subtypes based on the route in which decreased methylation and a failure of epigenetic repression occurs. About 95% of cases of FSHD are Type 1, in which D4Z4 repeats become lost. The remaining 5% of FSHD cases classify as Type 2, in which methylation and epigenetics are affected in a deletion-independent manner. Regardless of the subtype, the result of FSHD is the same.
FSHD can mimic many other genetic myopathies: particularly limb-girdle muscular dystrophy, subacute necrotizing encephalomyelopathy, acid maltase deficiency, myotonic dystrophy, and polymyositis. In cases of significant symptom overlap between myopathies, genetic testing remains the standard in distinguishing between disease pathology.
Facioscapulohumeral Muscular Dystrophy (FSHD) Market Key Facts
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In 2021, the total Facioscapulohumeral Muscular Dystrophy market size was USD 25.55 million in the 7MM.
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The total Facioscapulohumeral Muscular Dystrophy market size in the United States was USD 19.83 million in 2021.
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In Japan, the total Facioscapulohumeral Muscular Dystrophy market size was USD 2.39 million in 2021.
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In the year 2021, the total Facioscapulohumeral Muscular Dystrophy prevalent cases were 78,790 in the 7MM.
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In the 7MM, the highest number of total prevalent cases of FSHD were observed in the United States, with 33,500+ cases in 2021.
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The total prevalent cases of FSHD in EU4 and the UK comprised 32,800+ cases in 2021 and are projected to increase by 2032.
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In EU4 and the UK, the highest number of total prevalent cases of FSHD was observed in Germany in 2021.
Facioscapulohumeral Muscular Dystrophy (FSHD) Market
The market outlook section of the report helps to build a detailed comprehension of the historical, current, and forecasted market size by analyzing the impact of current and emerging Facioscapulohumeral Muscular Dystrophy pipeline therapies. It also thoroughly assesses the Facioscapulohumeral Muscular Dystrophy market drivers & barriers, unmet needs, and emerging technologies set to impact the market dynamics.
The report gives complete detail of the market trend for each marketed Facioscapulohumeral Muscular Dystrophy drug and mid & late-stage pipeline therapies by evaluating their impact based on the annual cost of therapy, their Mechanism of Action (MOA), Route of Administration (ROA), molecule types, competition with other therapies, brand value, and their impact on the market.
Facioscapulohumeral Muscular Dystrophy (FSHD) Epidemiology Assessment
The epidemiology section provides insights into the historical, current, and forecasted Facioscapulohumeral Muscular Dystrophy epidemiology trends in the seven major countries (7MM) from 2019 to 2032. It helps to recognize the causes of current and forecasted Facioscapulohumeral Muscular Dystrophy epidemiology trends by exploring numerous studies and research. The epidemiology section also provides a detailed analysis of diagnosed and prevalent patient pools, future trends, and views of key opinion leaders.
The Report Covers the Facioscapulohumeral Muscular Dystrophy Epidemiology, Segmented as –
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Total Prevalent Cases of Facioscapulohumeral Muscular Dystrophy
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Total Diagnosed Cases of Facioscapulohumeral Muscular Dystrophy
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Total Type-specific Cases of Facioscapulohumeral Muscular Dystrophy
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Total Gender-specific Cases of Facioscapulohumeral Muscular Dystrophy
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Total Age-specific Cases of Facioscapulohumeral Muscular Dystrophy
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Total Severity-specific Cases of Facioscapulohumeral Muscular Dystrophy
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Total Treated Cases of Facioscapulohumeral Muscular Dystrophy
Facioscapulohumeral Muscular Dystrophy (FSHD) Drugs Uptake and Pipeline Development Activities
The drug uptake section focuses on the uptake rate of potential drugs recently launched in the Facioscapulohumeral Muscular Dystrophy market or expected to be launched during the study period. The analysis covers the Facioscapulohumeral Muscular Dystrophy market uptake by drugs, patient uptake by therapies, and sales of each drug. Moreover, the therapeutics assessment section helps understand the market dynamics by drug sales, the most rapid drug uptake, and the reasons behind the maximal use of particular drugs. Additionally, it compares the Facioscapulohumeral Muscular Dystrophy drugs based on their sale and market share.
The report also covers the Facioscapulohumeral Muscular Dystrophy pipeline development activities. It provides valuable insights about different therapeutic candidates in various stages and the key Facioscapulohumeral Muscular Dystrophy companies involved in developing targeted therapeutics. It also analyzes recent developments such as collaborations, acquisitions, mergers, licensing patent details, and other information for emerging therapies.
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Facioscapulohumeral Muscular Dystrophy (FSHD) Therapeutics Analysis
There are currently no disease-modifying treatments for FSHD; supportive care is the mainstay of managing FSHD. This care primarily occurs in the context of physical therapy and rehabilitation exercises. Managing pain and fatigue in FSHD patients is essential, as both symptoms can affect patient psychology. Chronic pain is manageable with analgesic and antidepressant therapy to improve the quality of life in FSHD patients
Several major pharma and biotech companies are developing therapies for Facioscapulohumeral Muscular Dystrophy. Several of the therapies are in the advanced stages of clinical development and are expected to hit the market in the near future.
Facioscapulohumeral Muscular Dystrophy (FSHD) Companies Actively Working in the Therapeutics Market Include
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Fulcrum Therapeutics
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Dyne Therapeutics.
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Hoffmann-La Roche
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aTyr Pharma, Inc.
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Avidity Biosciences, Inc.
And Many Others
Emerging and Marketed Facioscapulohumeral Muscular Dystrophy (FSHD) Therapies Covered in the Report Include:
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Losmapimod: Fulcrum Therapeutics
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DYNE-301: Dyne Therapeutics
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AOC 1020: Avidity Biosciences
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MC-DX4: miRecule
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Losmapimod: Fulcrum Therapeutics
And Many More
The Report Covers an In-depth Assessment of Emerging Drugs and key Companies. Download the Sample Report to Learn More @
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Table of Content (TOC)
1. Key Insights
2. Executive Summary
3. Facioscapulohumeral Muscular Dystrophy Competitive Intelligence Analysis
4. Facioscapulohumeral Muscular Dystrophy Market Overview at a Glance
5. Facioscapulohumeral Muscular Dystrophy Disease Background and Overview
6. Facioscapulohumeral Muscular Dystrophy Patient Journey
7. Facioscapulohumeral Muscular Dystrophy Patient Population and Epidemiology Trends (In the US, EU5, and Japan)
8. Facioscapulohumeral Muscular Dystrophy Treatment Algorithm, Current Treatment, and Medical Practices
9. Facioscapulohumeral Muscular Dystrophy Unmet Needs
10. Key Endpoints of Facioscapulohumeral Muscular Dystrophy Treatment
11. Facioscapulohumeral Muscular Dystrophy Marketed Therapies
12. Facioscapulohumeral Muscular Dystrophy Emerging Drugs and Latest Therapeutic Advances
13. Facioscapulohumeral Muscular Dystrophy Seven Major Market Analysis
14. Attribute Analysis
15. Facioscapulohumeral Muscular Dystrophy Market Outlook (In US, EU5, and Japan)
16. Facioscapulohumeral Muscular Dystrophy Companies Active in the Market
17. Facioscapulohumeral Muscular Dystrophy Access and Reimbursement Overview
18. KOL Views on the Facioscapulohumeral Muscular Dystrophy Market
19. Facioscapulohumeral Muscular Dystrophy Market Drivers
20. Facioscapulohumeral Muscular Dystrophy Market Barriers
21. Appendix
22. DelveInsight Capabilities
23. Disclaimer
*The Table of Contents (TOC) is not exhaustive; the final content may vary. Refer to the sample report for the complete table of contents.
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About DelveInsight
DelveInsight is a leading Business Consultant and Market Research Firm focused exclusively on life sciences. It supports pharma companies by providing comprehensive end-to-end solutions to improve their performance.
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