Global Transfection Reagent and Equipment Market is expected to reach USD 649.20 million by 2025 and is projected to register a CAGR of healthy rate in the forecast period 2018 to 2025. The new market report contains data for historic years 2016, the base year of calculation is 2017 and the forecast period is 2018 to 2025.
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Some of the prominent participants operating in this market are Thermo Fisher Scientific Inc., QIAGEN, Promega Corporation, Bio-Rad Laboratories, Inc., MAXCYTE, INC., LONZA, Polyplus-transfection SA, Mirus Bio LLC, Sigma-Aldrich, Inc., Sigma-Aldrich, Inc., Genlantis, Inc., among others.
Thermo Fischer Inc:
Thermo Fischer Inc was incorporated in 1956 and headquartered in Massachusetts, U.S. CliniSys and MIPS are the two component companies of the CliniSys Group and they all operate directly from development, support and business operations centres strategically. The company is involved in manufacturing of analytical instruments, equipment’s, reagents, and consumables, software, and services for research, manufacturing, analysis, discovery. The company is mainly focused on offering Life Sciences Solutions Segment, Analytical Instruments Segment, Specialty Diagnostics Segment, Laboratory Products and Services. Market focused segment is Laboratory Products and Services Segment.
The company has its subsidiaries namely Laboratory Management Systems, Inc (U.S.), Fisher Clinical Logistics LLC (U.S.), TFLP LLC (U.S.), Cohesive Technologies Inc. (U.S.) , Thermo Fisher GP LLC (U.S.), D-finitive Technologies, Inc (U.S.), Thermo CRS Holdings Ltd (Canada), NAPCO, Inc. (U.S.) and among others
Thermo Fisher Inc has its presence in Europe, Middle East and Africa, Asia-Pacific , America.
Sigma –Aldrich Inc
Founded in 1975 and headquartered in Missouri, U.S. Sigma –Aldrich Inc. involved in development, manufacturing, purchasing and distribution of chemicals, biochemicals, and equipment. The company operates analytical chromatography, chemistry, life sciences, material sciences, green alternatives, custom products, services, labware. The transfection reagents and equipment lie under life sciences. The company is certified by ISO 9001:2015 standard, ISO 13485, ISO 17034 / ISO Guide 34, ISO-17025, OHSAS 18001, ISO 22000 Food Standard.
The company has its global presence in many regions such as North America, Europe, Asia-Pacific, Middle East and Africa, South America
Segmentation: Global Transfection Reagents and Equipment Market
Global Transfection Reagents and Equipment Market, By Product (Reagents, Equipment), By Method (Physical Method, Biochemical Methods, Viral Methods), By Application (Protein Production, Biomedical Research, Therapeutic Delivery), By End User (Academics & Research Institutes, Pharmaceutical & Biotechnology Companies), By Geography (North America, Europe, Asia-Pacific, South America, Middle East and Africa) – Industry Trends and Forecast to 2025
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Drivers: Global Transfection Reagents and Equipment Market
Prominent factors driving the growth of this market consist of technology advancements in the transfection technology, rising prevalence of chronic cases, increase in demand of chimeric genes growing alliances between the leading research institutes to trigger drug discovery, increasing R&D spending and research activities by pharmaceutical and biotech companies and rising research activities in cell science.
Rising Research Activities in Cell Science and increase in demand of chimeric genes
Transfection reagents and equipment facilitates insertion of the foreign gene into the animal model or different cell line. To design a chimeric organism foreign gene is inserted into the host organism’s gene. In cell biology, the designing of chimeric models for experimental purpose plays a major role. Rising prevalence of various diseases, results in increase in research of new drug discovery in pharmaceuticals and biotechnology. Transfection reagents and equipment have applications in the plant biotechnology; it is used in designing pest resistance or drought resistance plant. Transfection is a valuable procedure in terms of molecular aspects in like ion channels allows the passage of ions in the same way transfection also creates pores for transfer of foreign DNA material. Various transfections techniques are developed for transfection of mammalian cells such as calcium phosphate based, lipid based, and electroporation.
Bombardment method is a one of the methods used in the plant cells where the cell wall is hard to deliver the genetic material into cytoplasm or plant nucleus using other methods. In HeLa P4 cells, the rate of transfection efficiency is quite high as compared to normal cells. Chemical transfection has lower transfection efficiencies and is used in in-vivo gene expression.
Many researches are going on chimeric genes which are modified genes that constitute of parent gene and foreign gene. For instance, Human surfactant protein C (SP-C) gene is inserted into pulmonary adenocarcinomas mouse model to study bronchiolo-alveolar stem cell homeostasis. Transfection reagent or equipment is required to study the effect of any particular gene. To study the function of a particular protein or protein production, targeted DNA or RNA is inserted in gene which produces chimeric gene. In designing of chimeric gene different viral vectors like Sendai virus vector (SeV vector), Simian immunodeficiency virus vector (SIV vector) are used where other transfection reagents and methods don’t work and to design specific experimental models which are possible with viral vectors only. In cell science, study of gene expression which has to be inserted in the organism is first checked for right expression and cytotoxicity of the organisms. In 2015, CRISPR-CAS-9 technique came into the role. This technology enables the researchers or scientist to alter the genome segments as per requirement. In this technology, a segment of DNA is transferred to the parent genome or is removed or replaced by the correct gene without altering the right gene expression. CRISPR-CAS-9 comprises of Cas-9 enzyme which cuts the DNA segment at specific location so that new gene segment can be added. This process is regulated by gRNA (guide RNA) which regulates Cas9 activity to make the proper incision at specific location.
CRISPR-CAS-9 technology helps in the study of gene–disease relationship and abnormalities of the disease.
Increasing research activities in pharmaceutical and biotechnology field are also accountable for enhancement of transfection reagent and equipment market. To study cancer, neurological disorder or any genetic disorder specific chimeric models are required to study the mechanism of action of drug or study about the disease. For particular disease specific chimeric organism with specific genes are required. Thus, the demand of chimeric gene is increasing with the surging demand for diseases targeted therapies. Therefore, the transfection reagent market is growing with increasing demand of chimeric gene.
Increasing R&D Spending and Research Activities By Pharmaceutical and Biotech Companies
Due to unhealthy lifestyle new disease are being diagnosed with no treatment availability. New drug development is necessary to develop better treatment options. In drug testing process experimental models or experimental cells are required designed to for the testing of the drug. To create the experimental model target gene or foreign gene is inserted into the defective or parent gene. Therefore, discovery of more disease results in designing of more experimental models which in turn increases the transfection reagent and equipment market.
Some of the developments made by key players are mentioned below:
- In February 2018, Lonza (Switzerland) started their new research and development centers South America in Salto, Brazil to initiate there research in biosciences. This research Centre will have Center of Excellence to share technologies, ingredients, diagnostic systems and knowledge.
- In October 2017, Lonza (Switzerland) opened a new research and development Centre in Israel. The main focus behind this research Centre is to accelerate the research in pharmaceutical and biotechnology.
- Bio-Rad Laboratories, Inc (U.S) reported that the successful transfection of SiRNA into the B-cell Lymphoma using the Gene Pulser MXcell electroporation system.
Expansion of research and development centers by the company in other countries to promote the research and development activities in the field of cell science or specific to transfection proves that the transfection reagents and equipment market is growing. In future the rate of growth of market may enhance due to more and more progressive research in transfection reagent and equipment market.
Alliances between the leading Research Institutes to Trigger Drug Discovery
With the increasing demand of the research and development the pharmaceutical and biotechnology companies are emphasizing more on development of new and latest reagents and equipment’s. For the development of upgraded technology the companies undergo various development agreements like merger and acquisition, licensing and collaboration, development partnerships agreement and others.
Few alliances in transfection reagent and equipment’s market are as follows.
- In August 2016, InvitroCue Limited (Singapore) signed the strategic partnership agreement with QIAGEN Suzhou Translational Medicine Co. Limited (China). As per this agreement InvitroCue will utilize the siRNA library and transfection reagents of the QIAGEN. This agreement has expanded company’s biomarker discovery and translational medicine research services.
In 2015, F. Hoffmann-La Roche Ltd (Switzerland) made a distribution agreement with Sigma-Aldrich, Inc. (U.S.). This agreement had given Sigma Aldrich the distribution rights for the Roche products like XTG9-RO, XTGHP-RO, SITRAN-RO and others worldwide.
- In March 2010, Techulon, Inc (U.S) signed a licensing agreement with University of Cincinnati (U.S). Through this agreement the company got the license to manufacture and sell novel transfection reagents which are used for research and therapeutic delivery of nucleic acids.
To promote the growth of the market and business expansion by many key players such as different agreements like distribution, license, research and development and distribution agreement with other companies. The rise in number of agreements for the developments of drugs is promoting the growth of transfection reagent and equipment market.
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