DelveInsight has launched a new report on “Graft versus host disease (GVHD)- Market Insight, Epidemiology and Market Forecast -2030”.
DelveInsight’s “Graft versus host disease (GVHD) – Market Insights, Epidemiology, and Market Forecast-2030“ report delivers an in-depth understanding of the Graft versus host disease (GVHD), historical and forecasted epidemiology as well as the Graft versus host disease (GVHD) market trends in the United States, EU5 (Germany, Spain, Italy, France, and United Kingdom) and Japan.
Some facts of the report:
- Based on DelveInsight’s analysis, total allogeneic HSCTs cases accounts for approximately 41.08% of total HSCTs cases, as there were XX allogeneic incident cases diagnosed in 2017, XX of which were first allogeneic HSCT (i.e., 84.83% of total allogeneic cases)..
- Among the EU5 countries, Germany has the highest HSCTs cases followed by France and Italy.
- DelveInsight estimates higher incidence of HSCTs in the United States among 7MM.
Key Benefits of the Report:
- Graft versus host disease (GVHD) Market report covers a descriptive overview and comprehensive insight of the Graft versus host disease (GVHD) epidemiology and Graft versus host disease (GVHD) market in the 7MM (the United States, EU5 (Germany, Spain, France, Italy, UK) & Japan.)
- Graft versus host disease (GVHD) market report provides insights on the current and emerging therapies.
- Graft versus host disease (GVHD) market report provides a global historical and forecasted market covering drug outreach in 7 MM.
- Graft versus host disease (GVHD) market report offers an edge that will help in developing business strategies by understanding trends shaping and driving the Graft versus host disease (GVHD) market.
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Graft versus host disease (GvHD) is a disease caused when cells from a donated stem cell graft attack the normal tissues of the transplant patient. Symptoms include jaundice, skin rash or blisters, a dry mouth, or dry eyes. GVHD occurs when a particular types of white blood cells (T cells) in the donated bone marrow or stem cells attack the host body cells because the donated cells (the graft) see the host cells as foreign and attack them.
GvHD has two types Acute GvHD and Chronic GvHD. Acute GvHD is also known as fulminant GVHD, and occurs usually in the initial 2-3 months after transplantation. While Chronic GVHD occurs around 3-4 months after the transplantation has happened, and has more diverse complications. This type affects liver, stomach, vagina, joints, lungs, gut, mouth and glands secreting mucous or saliva.
Acute GVHD is staged and graded (grade I-IV) by the number and extent of organ involvement. While Chronic GvHD is staged according to a new clinical scoring system on a four point scale (0-3) with 0 representing no involvement, 1 representing mild involvement (no significant impairment of daily living), 2 representing moderate involvement (significant impairment of daily living) and 3 representing severe impairment (major disability).
“According to Delveinsight, No significant difference was found in incidence of GvHD among male and female”
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The launch of the emerging therapies is expected to significantly impact Graft versus host disease (GvHD) treatment scenario in the upcoming years:-
Drugs covered:
- Imbruvica
- Temcell HS
- Ruxolitinib
- Itacitinib
- Allocetra
- ATIR101
- CD24Fc
- And Many Others
The key players in Graft versus host disease (GvHD) market are:
- Imbruvica
- Temcell HS
- Incyte Corporation
- Enlivex Therapeutics
- Kiadis Pharma
- OncoImmune
- And Many Others
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Table of Contents:
1. Report Introduction
2. GvHD Market Overview at a Glance
2.1. Market Share Distribution of GvHD in 2017
2.2. Market Share Distribution of GvHD in 2030
3. Disease Background and Overview: Graft versus Host Disease (GvHD)
3.1. Introduction
3.2. Disease Types
3.3. Acute GvHD
3.4. Chronic GvHD
3.5. Grades of GvHD
3.6. Pathophysiology
3.7. Risk Factors for GVHD
3.8. Diagnosis
4. Epidemiology and Patient Population
4.1. Key Findings
4.2. Population and Forecast Parameters
4.3. Diagnosed Incident Cases of Hematopoietic Stem Cell Transplantations in 7MM
4.4. Diagnosed Incident Cases of aGvHD in Diagnosed Incident Cases of First Allogeneic HSCTs in 7MM– By Region
4.5. Diagnosed Incident Cases of cGvHD in Diagnosed Incident Cases of First Allogeneic HSCTs in 7MM– By Region
4.6. 4-Year Diagnosed Prevalent Cases of aGvHD in First Allogeneic HSCTs in 7MM-2016
4.7. 4-Year Diagnosed Prevalent Cases of aGvHD in First Allogeneic HSCTs in 7MM-2027
4.8. 5-Year Diagnosed Prevalent Cases of cGvHD in First Allogeneic HSCTs in 7MM-2016
4.9. 5-Year Diagnosed Prevalent Cases of cGvHD in First Allogeneic HSCTs in 7MM-2027
5. Epidemiology of Graft Versus Host Disease
6. United States
6.1. Assumptions and Rationale
6.2. Diagnosed Incident Cases of Hematopoietic Stem Cell Transplantations (HSCTs) in United States
6.3. Diagnosed Incident Cases of Allogeneic HSCT in United States
6.4. Diagnosed incident cases of aGvHD in diagnosed incident cases of first allogeneic HSCTs in US
6.5. Incident cases of aGvHD by Grades in US
6.6. Diagnosed incident cases of cGvHD in diagnosed incident cases of first allogeneic HSCTs in US
6.7. 4-Year Diagnosed Prevalent Cases of aGvHD in First Allogeneic HSCTs in United States
6.8. 5-Year Diagnosed Prevalent Cases of cGvHD in First Allogeneic HSCTs in United States
7. EU5
7.1. Assumptions and Rationale
7.2. Germany
7.2.1. Diagnosed Incident Cases of Hematopoietic Stem Cell Transplantations (HSCTs) in Germany
7.2.2. Diagnosed Incident Cases of Allogeneic HSCT in Germany
7.2.3. Diagnosed incident cases of aGvHD in diagnosed incident cases of first allogeneic HSCTs in Germany
7.2.4. Incident cases of aGvHD by Grades in Germany
7.2.5. Diagnosed incident cases of cGvHD in diagnosed incident cases of first allogeneic HSCTs in Germany
7.2.6. 4-Year Diagnosed Prevalent Cases of aGvHD in First Allogeneic HSCTs in Germany
7.2.7. 5-Year Diagnosed Prevalent Cases of cGvHD in First Allogeneic HSCTs in Germany
7.3. France
7.3.1. Diagnosed Incident Cases of Hematopoietic Stem Cell Transplantations (HSCTs) in France
7.3.2. Diagnosed Incident Cases of Allogeneic HSCT in France
7.3.3. Diagnosed incident cases of aGvHD in diagnosed incident cases of first allogeneic HSCTs in France
7.3.4. Incident cases of aGvHD by Grades in France
7.3.5. Diagnosed incident cases of cGvHD in diagnosed incident cases of first allogeneic HSCTs in France
7.3.6. 4-Year Diagnosed Prevalent Cases of aGvHD in First Allogeneic HSCTs in France
7.3.7. 5-Year Diagnosed Prevalent Cases of cGvHD in First Allogeneic HSCTs in France
7.4. Italy
7.4.1. Diagnosed Incident Cases of Hematopoietic Stem Cell Transplantations (HSCTs) in Italy
7.4.2. Diagnosed Incident Cases of Allogeneic HSCT in Italy
7.4.3. Diagnosed incident cases of aGvHD in diagnosed incident cases of first allogeneic HSCTs in Italy
7.4.4. Incident cases of aGvHD by Grades in Italy
7.4.5. Diagnosed incident cases of cGvHD in diagnosed incident cases of first allogeneic HSCTs in Italy
7.4.6. 4-Year Diagnosed Prevalent Cases of aGvHD in First Allogeneic HSCTs in Italy
7.4.7. 5-Year Diagnosed Prevalent Cases of cGvHD in First Allogeneic HSCTs in Italy
7.5. Spain
7.5.1. Diagnosed Incident Cases of Hematopoietic Stem Cell Transplantations (HSCTs) in Spain
7.5.2. Diagnosed Incident Cases of Allogeneic HSCT in Spain
7.5.3. Diagnosed incident cases of aGvHD in diagnosed incident cases of first allogeneic HSCTs in Spain
7.5.4. Incident cases of aGvHD by Grades in Spain
7.5.5. Diagnosed incident cases of cGvHD in diagnosed incident cases of first allogeneic HSCTs in Spain
7.5.6. 4-Year Diagnosed Prevalent Cases of aGvHD in First Allogeneic HSCTs in Spain
7.5.7. 5-Year Diagnosed Prevalent Cases of cGvHD in First Allogeneic HSCTs in Spain
7.6. United Kingdom
7.6.1. Diagnosed Incident Cases of Hematopoietic Stem Cell Transplantations (HSCTs) in UK
7.6.2. Diagnosed Incident Cases of Allogeneic HSCT in UK
7.6.3. Diagnosed incident cases of aGvHD in diagnosed incident cases of first allogeneic HSCTs in UK
7.6.4. Incident cases of aGvHD by Grades in UK
7.6.5. Diagnosed incident cases of cGvHD in diagnosed incident cases of first allogeneic HSCTs in UK
7.6.6. 4-Year Diagnosed Prevalent Cases of aGvHD in First Allogeneic HSCTs in UK
7.6.7. 5-Year Diagnosed Prevalent Cases of cGvHD in First Allogeneic HSCTs in UK
8. Japan
8.1. Assumptions and Rationale
8.2. Diagnosed Incident Cases of Hematopoietic Stem Cell Transplantations (HSCTs) in Japan
8.3. Diagnosed Incident Cases of Allogeneic HSCT in Japan
8.4. Diagnosed incident cases of aGvHD in diagnosed incident cases of first allogeneic HSCTs in Japan
8.5. Incident cases of aGvHD by grades in Japan
8.6. Diagnosed incident cases of cGvHD in diagnosed incident cases of first allogeneic HSCTs in Japan
8.7. 4-Year Diagnosed Prevalent Cases of aGvHD in First Allogeneic HSCTs in Japan
8.8. 5-Year Diagnosed Prevalent Cases of cGvHD in First Allogeneic HSCTs in Japan
9. Treatment Algorithm
9.1. Guidelines and Recommendations for Treatment of GvHD
9.2. United States
9.3. Europe
9.4. Japan
10. Unmet Needs
11. Marketed Drugs
11.1.1.Imbruvica
11.1.2.Product Description
11.1.3.Regulatory Milestones
11.1.4.Advantages & Disadvantages
11.1.5.Product Profile
11.1.6.Safety and Efficacy of Imbruvica
11.1.7.Side effects of Imbruvica
11.2. Temcell HS
11.2.1.Product Description
11.2.2.Regulatory Milestones
11.2.3.Advantages & Disadvantages
11.2.4.Product Profile
11.2.5.Safety and Efficacy of Temcell HS
11.2.6.Side effects of Temcell HS
To be continued in report
12. Emerging Therapies
12.1. Key Cross Competition
13. Therapeutics
13.1. Ruxolitinib: Incyte Corporation
13.1.1.Product Description
13.1.2.Other development activities
13.1.3.Clinical Development
13.1.4.Clinical Trials Information
13.1.5.Safety and Efficacy
13.1.6.Advantages and Disadvantages
13.1.7.Product Profile
13.2. Itacitinib: Incyte Corporation
13.2.1.Product Description
13.2.2.Other development activities
13.2.3.Clinical Development
13.2.4.Clinical Trials Information
13.2.5.Safety and Efficacy
13.2.6.Advantages and Disadvantages
13.2.7.Product Profile
14. Prophylaxis
14.1. Allocetra: Enlivex Therapeutics
14.1.1.Product Description
14.1.2.Other development activities
14.1.3.Clinical Development
14.1.4.Safety and Efficacy
14.1.5.Advantages and Disadvantages
14.1.6.Product Profile
14.2. ATIR101: Kiadis Pharma
14.2.1.Product Description
14.2.2.Other development activities
14.2.3.Clinical Development
14.2.4.Clinical Trials Information
14.2.5.Safety and Efficacy
14.2.6.Advantages and Disadvantages
14.2.7.Product Profile
15. Other Promising Candidates
15.1. CD24Fc: OncoImmune
15.1.1.Product Description
15.1.2.Other development activities
15.1.3.Clinical Development
15.1.4.Clinical Trials Information
15.1.5.Safety and Efficacy
15.1.6.Product Profile
15.1.7.To be continued in report
16. Total Market Size of GvHD in 7MM
17. 7MM Market Size by Therapies
18. United States-GvHD Market
18.1. Market Outlook
18.2. US Market Size by Therapies
18.3. Total Market Size of GVHD in United States
18.4. Market Size of Prophylaxis GVHD in United States
18.5. Market Size of aGVHD in United States
18.6. Market Size of cGVHD in United States
19. EU5-GvHD Market
19.1. Market Outlook
19.2. EU5 Market Size by Therapies
19.3. Total Market Size of GVHD in EU5
19.4. Germany
19.4.1. Total Market Size of GVHD in Germany
19.4.2. Market Size of Prophylaxis GVHD in Germany
19.4.3. Market Size of aGVHD in Germany
19.4.4. Market Size of cGVHD in Germany
19.5. France
19.5.1. Total Market Size of GVHD in France
19.5.2. Market Size of Prophylaxis GVHD in France
19.5.3. Market Size of aGVHD in France
19.5.4. Market Size of cGVHD in France
19.6. Italy
19.6.1. Total Market Size of GVHD in Italy
19.6.2. Market Size of Prophylaxis GVHD in Italy
19.6.3. Market Size of aGVHD in Italy
19.6.4. Market Size of cGVHD in Italy
19.7. Spain
19.7.1. Total Market Size of GVHD in Spain
19.7.2. Market Size of Prophylaxis GVHD in Spain
19.7.3. Market Size of aGVHD in Spain
19.7.4. Market Size of cGVHD in Spain
19.8. United Kingdom
19.8.1. Total Market Size of GVHD in UK
19.8.2. Market Size of Prophylaxis GVHD in UK
19.8.3. Market Size of aGVHD in UK
19.8.4. Market Size of cGVHD in UK
20. Japan-GvHD Market
20.1. Market Outlook
20.2. Japan Market Size by Therapies
20.3. Total Market Size of GVHD in Japan
20.4. Market Size of Prophylaxis GVHD in Japan
20.5. Market Size of aGVHD in Japan
20.6. Market Size of cGVHD in Japan
21. Market Drivers
22. Market Barriers
23. Appendix
24. Report Methodology
24.1. Sources Used
25. Consulting Services
26. Disclaimer
27. About DelveInsight
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