DelveInsight’s, “Malaria Pipeline Insight, 2022,” report provides comprehensive insights about 15+ companies and 20+ pipeline drugs in the Malaria pipeline landscape. It covers the pipeline drug profiles, including clinical and nonclinical stage products. It also covers the therapeutics assessment by product type, stage, route of administration, and molecule type. It further highlights the inactive pipeline products in this space.
Key takeaways from the Malaria Pipeline Report
- DelveInsight’s MalariaPipeline report depicts a robust space with 15+ active players working to develop 20+ pipeline therapies for Malaria treatment.
- The leading Malaria Companies included such as Sanaria, Novartis, GlaxoSmithKline, Lyndra Therapeutics, Tarsus Pharmaceuticals, GeoVax, Bharat Biotech, Sumitomo Pharma, Zymergen, and others are developing potential drug candidates to improve the Malaria treatment scenario.
- The promising Malaria therapies in the pipeline included such as KAE609, Coartem, PfSPZ Vaccine, KAF156, RTS,S/AS01E (SB257049), PfSPZ Vaccine, CHMI (NF135.C10), and others
- Companies and academics are working to assess challenges and seek opportunities that could influence Malaria R&D. The therapies under development are focused on novel approaches to treat/improve Malaria.
- This segment of the Malaria report encloses its detailed analysis of various drugs in different stages of clinical development, including phase II, I, preclinical and Discovery. It also helps to understand clinical trial details, expressive pharmacological action, agreements and collaborations, and the latest news and press releases.
Get an overview of the pipeline landscape @ Malaria Pipeline Outlook
Malaria Overview
Malaria is a life-threatening disease caused by parasites that are transmitted to people through the bites of infected female Anopheles mosquitoes. It is preventable and curable. In 2019, there were an estimated 229 million cases of malaria worldwide. Malaria is caused by Plasmodium parasites. The parasites are spread to people through the bites of infected female Anopheles mosquitoes, called “malaria vectors.” There are 5 parasite species that cause malaria in humans, and 2 of these species – P. falciparum and P. vivax – pose the greatest threat. Malaria is an acute febrile illness. In a non-immune individual, symptoms usually appear 10–15 days after the infective mosquito bite.
The first symptoms – fever, headache, and chills – may be mild and difficult to recognize as malaria. If not treated within 24 hours, P. falciparum malaria can progress to severe illness, often leading to death. Early diagnosis and treatment of malaria reduces disease and prevents deaths. Antimalarial medicines can also be used to prevent malaria. For travellers, malaria can be prevented through chemoprophylaxis, which suppresses the blood stage of malaria infections, thereby preventing malaria disease. The most common antimalarial drugs include: Chloroquine phosphate, Chloroquine is the preferred treatment for any parasite that is sensitive to the drug.
Latest Breakthroughs and Developments in the Malaria Treatment Landscape
Cipargamin is the first antimalarial drug candidate with a novel mechanism of action to achieve positive clinical proof-of-concept in over 20 years. Cipargamin, the first compound in the spiroindolone class of treatment, works through a novel mechanism of action that involves inhibition of a P-type cation-transporter ATPase4 (PfATP4), which regulates sodium concentration in the parasite. Because Cipargamin also appears to be effective against the sexual forms of the parasite, it could potentially help prevent disease transmission. Cipargamin was tested in adult patients with uncomplicated malaria and showed a median parasite clearance time of 12 hours, including in patients with resistant infections. Currently the product is in Phase II stage of development for the treatment of Malaria.
Malaria Emerging Drugs
- Cipargamin: Novartis
Malaria Pipeline Therapeutics Analysis
There are approx. 15+ key companies which are developing the therapies for Malaria. The companies which have their Malaria drug candidates in the most advanced stage, i.e. Phase I include Novartis.
For further information, refer to the detailed report @ Malaria Emerging Therapies
DelveInsight’s Malaria Pipeline Report covers around 20+ products under different phases of clinical development-
- Late stage products (Phase III)
- Mid-stage products (Phase II)
- Early-stage product (Phase I) along with the details of
- Pre-clinical and Discovery stage candidates
- Discontinued & Inactive candidates
Scope of the Malaria Pipeline Report
- Coverage- Global
- Malaria Companies- Sanaria, Novartis, GlaxoSmithKline, Lyndra Therapeutics, Tarsus Pharmaceuticals, GeoVax, Bharat Biotech, Sumitomo Pharma, Zymergen, and others
- Malaria therapies- KAE609, Coartem, PfSPZ Vaccine, KAF156, RTS,S/AS01E (SB257049), PfSPZ Vaccine, CHMI (NF135.C10), and others
- Malaria Therapeutic Assessment by Product Type
- Malaria Therapeutic Assessment by Stage and Product Type
- Malaria Therapeutic Assessment by Route of Administration
- Malaria Therapeutic Assessment by Stage and Route of Administration
- Malaria Therapeutic Assessment by Molecule Type
- Malaria Therapeutic Assessment by Stage and Molecule Type
- Malaria companies’ collaborations, Licensing, Acquisition -Deal Value Trends
Table of Content
- Introduction
- Executive Summary
- Malaria: Overview
- Pipeline Therapeutics
- Therapeutic Assessment
- Malaria– DelveInsight’s Analytical Perspective
- Mid Stage Products (Phase II)
- PfSPZ Vaccine: Sanaria
- Mid Stage Products (Phase II)
- Cipargamin: Novartis
- Early Stage Products (Phase I/II)
- Company name: Drug name
- Early Stage Products (Phase I)
- INE963: Novartis
- Preclinical Stage Products
- Lotilaner: Tarsus Pharmaceuticals
- Inactive Products
- Malaria Key Companies
- Malaria Key Products
- Malaria- Unmet Needs
- Malaria- Market Drivers and Barriers
- Malaria- Future Perspectives and Conclusion
- Malaria Analyst Views
- Malaria Key Companies
- Appendix
Got Queries? Reach out for more information on the Malaria Pipeline Report- Malaria Pipeline Therapeutic Assessment
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