Pulmonary Arterial Hypertension Pipeline

DelveInsight’s Pulmonary Arterial Hypertension pipeline report provides comprehensive insights into the pipeline landscape for 55+ companies and 55+ pipeline drugs in Pulmonary Arterial Hypertension. It includes clinical and nonclinical stage products in the pipeline drug profiles. 

Some of the Key Highlights from the Pulmonary Arterial Hypertension Pipeline Report

• There are currently 55+ drugs in the Pulmonary Arterial Hypertension pipeline.

• The Pulmonary Arterial Hypertension pipeline comprises therapies that are in different stages of the clinical phase include Sotatercept, Seralutinib, BIA 5-1058, PF-06842874, AER-901, Belapectin, and others and are expected to be available for Pulmonary Arterial Hypertension treatment soon.

• Several pharmaceutical companies are evaluating their drug candidates for Pulmonary Arterial Hypertension treatment include Acceleron Pharma, Bristol Myers Squibb, Gossamer Bio, Bial, Pfizer, Aerami Therapeutics, Galectin Therapeutics, among others.

• Sotatercept (Acceleron Pharma/Bristol Myers Squibb) has received Orphan Drug and Breakthrough Therapy designations from the US Food and Drug Administration (FDA) for the treatment of Pulmonary Arterial Hypertension while the European Medicines Agency (EMA) has designated sotatercept as a Priority Medicine (PRIME) for the treatment of Pulmonary Arterial Hypertension.

• Some other pipeline therapies in the late-stage clinical development for Pulmonary Arterial Hypertension include Seralutinib (Gossamer Bio), BIA 5-1058 (Bial), along with others.

• Belapectin (Galectin Therapeutics) is in the early stages of development i.e. preclinical stage for Pulmonary Arterial Hypertension treatment.

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Pulmonary Arterial Hypertension: Overview

Pulmonary Arterial Hypertension (PAH) is a rare, progressive disorder characterized by abnormally high blood pressure (hypertension) in the arteries of the lungs (pulmonary artery). The blood vessels that carry blood from the right side of the heart to the lungs are known as the pulmonary arteries.

Pulmonary Arterial Hypertension Symptoms

The most common Pulmonary Arterial Hypertension symptom is severe shortness of breath after exertion. Excessive fatigue, weakness, chest pain, dizzy spells, and fainting episodes are also PAH symptoms. Affected people may also have a cough, sometimes with blood (hemoptysis), an enlarged heart and liver, low blood pressure (hypotension), and hoarseness due to an enlarged pulmonary artery compressing a nerve in the chest.

Pulmonary Arterial Hypertension Treatment

The FDA has approved several drugs such as Flolan (epoprostenol sodium for injection or prostacycline), Treprostinil (Remodulin), Iloprost (Ventavis), Revatio (sildenafil), and others that are used to treat Pulmonary Arterial Hypertension.

Pulmonary Arterial Hypertension Pipeline Analysis: Drug Profiles

Sotatercept:  Acceleron Pharma/Bristol Myers Squibb

Product Description

Sotatercept is being tested on patients suffering from pulmonary arterial hypertension (PAH), a rare, progressive, and potentially fatal blood vessel disorder. Sotatercept is a ligand trap with high selectivity for multiple TGF-beta superfamily members.

Phase III

NCT04796337: Acceleron Pharma began the trial in May 2021. This study is being conducted to evaluate the long-term safety, tolerability, and efficacy of Sotatercept in PAH.

Pulmonary Arterial Hypertension Pipeline Therapies and Key Companies

• Sotatercept:  Acceleron Pharma/ Bristol Myers Squibb

• Seralutinib: Gossamer Bio

• BIA 5-1058: Bial

• PF-06842874: Pfizer

• AER-901: Aerami Therapeutics

• Belapectin: Galectin Therapeutics

For more information on the emerging drugs and companies, visit Clinical Trial Design and New Therapies for Pulmonary Arterial Hypertension

Pulmonary Arterial Hypertension Therapeutics Assessment

• By Product Type

• Monotherapy

• Combination Therapy

• By Stage

• Discovery

• Pre-Clinical

• Phase I

• Phase II

• Phase III

• Pre-registration

• By Route of Administration

• Inhalation

• Intravenous

• Oral

• Subcutaneous

• By Molecule Type

• Small Molecule

• Stem Cell Therapy

• Gene Therapy

• Targets

• Immune System

• Multiple Kinase

• By Mechanism of Action

• Protease Inhibitors

• Immunomodulatory

Scope of the Report

Coverage: Global

Pulmonary Arterial Hypertension Key Players: Acceleron Pharma, Bristol Myers Squibb, Gossamer Bio, Bial, Pfizer, Aerami Therapeutics, Galectin Therapeutics, among others

Pulmonary Arterial Hypertension Pipeline Therapies: Sotatercept, Seralutinib, BIA 5-1058, PF-06842874, AER-901, Belapectin, and others

Table of Contents

For rich insights into Healthcare and Pharmaceutical News, visit Pharma, Healthcare, and Biotech Blog Posts

Key questions answered in the Pulmonary Arterial Hypertension Pipeline Report

• What are the options for treating pulmonary arterial hypertension?

• How many pharmaceutical companies are working on treatments for pulmonary arterial hypertension?

• Which of these firms’ pharmaceuticals is the most widely used?

• How many pulmonary arterial hypertension medications does each company produce in total?

• How many drugs are in the pipeline for pulmonary arterial hypertension that are in the early, middle, or late stages of development?

• How many of the therapies currently in development can be used alone or in conjunction with other treatments?

• What are the most important industry-industry and industry-academy collaborations, mergers and acquisitions, and licensing practices influencing pulmonary arterial hypertension?

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Pulmonary Hypertension Pipeline Insights

Get a comprehensive analysis of Pulmonary Hypertension pipeline therapies and key companies including Johnson & Johnson Services, Inc., United Therapeutics Corporation, Pfizer, Inc., Acceleron Pharma, Inc., Gilead Sciences, Inc., Bayer AG., GlaxoSmithKline Plc. (GSK), among others.

About DelveInsight

DelveInsight is a leading Business Consultant and Market Research firm focused exclusively on life sciences. It supports Pharma companies by providing end-to-end comprehensive solutions to improve their performance. 

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