There is a strong need for regional Sezary Syndrome registration centers, which may offer consented and consistent therapy recommendations, to gain more data and knowledge of this rare but threatening disease. Upcoming therapies, such as Medivir’s Remetinostat, Elorac’s Naloxone Hydrochloride, and several others, can potentially create a significant positive shift in the Sezary Syndrome treatment scenario in the coming years.
DelveInsight’s “Sezary Syndrome Market Insights, Epidemiology, and Market Forecast 2032” report delivers an in-depth understanding of the disease, historical and forecasted epidemiology, as well as the Sezary Syndrome market size, share, trends, and growth opportunities in the seven major markets (7MM) (i.e., the United States, EU4 (Germany, Spain, Italy, France), the United Kingdom and Japan).
The Sezary Syndrome market report covers emerging drugs, current treatment practices, market share of individual therapies, and current & forecasted market size from 2019 to 2032. It also evaluates the current treatment practice/algorithm, key drivers & barriers impacting the market growth, and unmet medical needs to curate the best of the opportunities and assess the underlying potential of the market.
Sezary Syndrome Overview
Sezary Syndrome is generally defined as the triad of erythroderma, generalized lymphadenopathy, and the presence of clonally related neoplastic T-cells with cerebriform nuclei (Sezary cells) in the skin, lymph nodes, and peripheral blood. It was first recognized as a separate clinical condition in the year 1938 and can be defined as the T-cell lymphoma of the skin and peripheral blood. Although Sezary Syndrome was initially identified as a separate variant of Mycosis Fungoides (MF), the recent WHO-EORTC combined classification scheme categorizes these two indications as different clinical entities with distinctive and characteristic clinical features.
Sezary Syndrome can affect people of all ages; it is most commonly diagnosed in adults over age 60. Although a small percentage of Sezary Syndrome cases are associated with human T-lymphotropic viruses type 1 and type 2; the exact cause is unclear. But most people with Sezary Syndrome have chromosomal abnormalities in the DNA of the cancerous cells, but not in healthy cells. These are not inherited defects but changes that happen over a lifetime.
Sezary Syndrome Market Key Facts
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The United States accounts for the largest market size of Sezary Syndrome, compared to EU5 (the United Kingdom, Germany, Italy, France, and Spain) and Japan.
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As per National Institute of Health (n.d.), Sézary syndrome is rare, although its prevalence is unknown. It is the second most common form of cutaneous T-cell lymphoma after mycosis fungoides, accounting for approximately 3−5% of cases.
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As per Cutaneous Lymphoma Foundation (n.d.), there are about 3,000 new cases of CTCL each year in the US, and approximately 15% of those are diagnosed with Sézary syndrome. Although Sézary syndrome can affect people of any age, Sézary syndrome is most common in adults ages 50 and over and is slightly more common in men than women.
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As per the study conducted by Dobos et al. (2020), the relative frequencies of Sezary Syndrome seemed to be globally stable at 3% and slightly more frequent in Europe.
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The study conducted by Hamada and Iwatsuki (2021) found that the proportion of patients with early-stage (IA to IIA) was 73%, similar to that of the previous studies (70.7% and 78%). Stage IB accounted for 39.1% of the total MF/SS in the present study, making it the most prevalent clinical stage.
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As per Larocca and Kupper (2019), the age-adjusted incidence rate for Sezary Syndrome is 0.1 per million persons. Men are more commonly affected than women (incidence rate ratio [IRR] = 1.6). The incidence increases with age, with the highest CTCL incidence at greater than 70 years of age.
Sezary Syndrome Market
The market outlook section of the report helps to build a detailed comprehension of the historical, current, and forecasted Sezary Syndrome market size by analyzing the impact of current and emerging pipeline therapies. It also provides a thorough assessment of the market drivers & barriers, unmet needs, and emerging technologies set to impact the market dynamics.
The report gives complete detail of the Sezary Syndrome market trend for each marketed drug and mid & late-stage pipeline therapies by evaluating their impact based on the annual cost of therapy, their Mechanism of Action (MOA), Route of Administration (ROA), molecule types, competition with other therapies, brand value, and their impact on the market.
Sezary Syndrome Epidemiology Assessment
The epidemiology section provides insights into the historical, current, and forecasted epidemiology trends in the seven major countries (7MM) from 2019 to 2032. It helps to recognize the causes of current and forecasted epidemiology trends by exploring numerous studies and research. The epidemiology section also provides a detailed analysis of diagnosed and prevalent patient pool, future trends, and views of key opinion leaders.
The Report Covers the Sezary Syndrome Epidemiology, Segmented by –
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Incidence of Cutaneous T-cell Lymphoma in the 7MM (2019-32)
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Number of Cases of Sezary Syndrome in the 7MM (2019-32)
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Gender-specific Cases of Sezary Syndrome in the 7MM (2019-32)
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Treatable Cases of Sezary Syndrome in the 7MM (2019-32)
Sezary Syndrome Drugs Uptake and Pipeline Development Activities
The drug uptake section focuses on the uptake rate of potential drugs recently launched in the Sezary Syndrome market or expected to be launched during the study period. The analysis covers the Sezary Syndrome market uptake by drugs, patient uptake by therapies, and sales of each drug. Moreover, the therapeutics assessment section helps understand the drugs with the most rapid uptake and the reasons behind the maximal use of the drugs. Additionally, it compares the drugs based on market share.
The report also covers the Sezary Syndrome pipeline development activities. It provides valuable insights about different therapeutic candidates in various stages and the key companies involved in developing targeted therapeutics. It also analyses recent developments such as collaborations, acquisitions, mergers, licensing patent details, and other information for emerging therapies.
Learn How the Sezary Syndrome Market Will Evolve and Grow by 2032 @ https://www.delveinsight.com/sample-request/sezary-syndrome-ss-market
Sezary Syndrome Therapeutics Analysis
Several major pharma and biotech giants are developing therapies for Sezary Syndrome. Currently, Innate Pharma is leading the therapeutics market with its Sezary syndrome drug candidates in the most advanced stage of clinical development.
The Leading Companies in the Sezary Syndrome Therapeutics Market Include:
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4SC AG
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Seagen Inc.
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Merck Sharp & Dohme Corp.
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Innate Pharma
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Trillium Therapeutics
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Secura Bio
And Many Others
Sezary Syndrome Drugs Covered in the Report Include:
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Resminostat: 4SC
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Lacutamab: Innate Pharma
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Naloxone Hydrochloride Lotion: Elorac
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Brentuximab vedotin: Seagen
And Many More
Table of Contents
1. Key Insights
2. Executive Summary
3. Sezary Syndrome Competitive Intelligence Analysis
4. Sezary Syndrome Market Overview at a Glance
5. Sezary Syndrome Disease Background and Overview
6. Sezary Syndrome Patient Journey
7. Sezary Syndrome Epidemiology and Patient Population (In the US, EU5, and Japan)
8. Sezary Syndrome Treatment Algorithm, Current Treatment, and Medical Practices
9. Sezary Syndrome Unmet Needs
10. Key Endpoints of Sezary Syndrome Treatment
11. Sezary Syndrome Marketed Products
12. Sezary Syndrome Emerging Drugs and Latest Therapeutic Advances
13. Sezary Syndrome Seven Major Market Analysis
14. Attribute Analysis
15. Sezary Syndrome Market Outlook (In US, EU5, and Japan)
16. Sezary Syndrome Access and Reimbursement Overview
17. KOL Views on the Sezary Syndrome Market
18. Sezary Syndrome Market Drivers
19. Sezary Syndrome Market Barriers
20. Appendix
21. DelveInsight Capabilities
22. Disclaimer
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